p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

International Journal of Cancer. Journal International Du Cancer
Takuo ShimmyoE Tsuchiya

Abstract

The question of whether squamous cell carcinomas (SCCs) arising in different sites of lung are caused by different etiological factors is of obvious importance for prevention, early detection and effective treatment. We here subclassified a large series of resected SCCs (74 cases) into 3 tumor-sites, central (main to segmental bronchi), intermediate (subsegmental to sub-subsegmental) and peripheral (distal to sub-subsegmental bronchi), and examined relationships with p53 mutational spectra and smoking history to provide clues to etiological factors. The rate for G-->A transitions at CpG sites considered to be caused by endogenous mechanism was higher in central (40%) than in intermediate (0%) and peripheral (14%) lesions, in spite of highest percentage of heavy smokers. In contrast, G-->T transversions associated with tobacco smoke carcinogens were most frequent (50%) in the intermediate location, although proportions of heavy smoker's ratio were the same among the locations when confined to p53 mutation cases. In the periphery, other mutations were highest (67%) compared with 33 and 50% in the central and intermediate regions, respectively. Thus, different etiological factors may be playing causal roles in the development of S...Continue Reading

References

Jan 1, 1992·American Industrial Hygiene Association Journal·T B Martonen
Nov 1, 1991·Cancer·O Auerbach, L Garfinkel
May 1, 1990·American Industrial Hygiene Association Journal·W J MullerP W Scherer
Nov 1, 1980·British Journal of Industrial Medicine·M LippmannR E Albert
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M F DenissenkoG P Pfeifer
Jul 17, 1999·British Journal of Cancer·Y TokuchiE Tsuchiya
Jul 21, 1999·Journal of the National Cancer Institute·S S Hecht
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·S N Rodin, A S Rodin
Jul 17, 2001·Chemical Research in Toxicology·D HoffmannK El-Bayoumy
Apr 12, 2002·Chest·Demosthenes BourosKyriaki Zeibecoglou
Oct 16, 2002·Oncogene·Gary A Giovino
Jun 27, 2003·The American Journal of Surgical Pathology·Kazuhito FunaiAtsushi Ochiai
Dec 3, 2003·Mutation Research·Glaucia R MartinezPaolo Di Mascio
Nov 16, 2004·Chemical Research in Toxicology·Kazuharu SeikeShosuke Kawanishi
Dec 1, 2004·Annual Review of Genetics·Deborah E Barnes, Tomas Lindahl
Jan 29, 2005·American Journal of Health Promotion : AJHP·Yumiko AsukaiYosuke Chikamoto
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniel R BrooksSteven D Stellman
Jun 21, 2005·Toxicology and Applied Pharmacology·Weiling Xue, David Warshawsky
Jul 7, 2005·Postgraduate Medical Journal·M Inoue, S Tsugane

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Citations

Jun 27, 2019·International Journal of Cancer. Journal International Du Cancer·Atsushi HataAtsushi Kaneda
Feb 13, 2007·Molecular Cancer Research : MCR·Wade S SamowitzHans Albertsen
Feb 4, 2021·International Journal of Cancer. Journal International Du Cancer·Atsushi HataAtsushi Kaneda

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