PMID: 9646035Jul 1, 1998Paper

p53 mutations in chondrosarcoma

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
R M TerekA P Albino

Abstract

Chondrosarcoma is a primary bone tumor that has several different grades and variants. We evaluated 48 chondrosarcomas for p53 overexpression and p53 mutations. p53 expression was evaluated with immunohistochemistry using monoclonal antibodies PAb421, PAb1801, and PAb240. p53 mutations were identified with single-strand conformational polymorphism (SSCP) and DNA sequencing in selected cases. Immunohistochemistry revealed nuclear staining with PAb421 and PAb1801 in the spindle cell portion of one dedifferentiated chondrosarcoma. SSCP analysis was abnormal only in the case with positive immunostaining and localized the mutation to exons 7 and 8. DNA sequence analysis identified a point mutation of G to C in codon 276, resulting in an amino acid substitution of proline for alanine. This point mutation has been reported previously in other tumors but not in chondrosarcoma. Assimilation of our results with previous studies suggests that p53 mutations are present in a minority of chondrosarcomas but when present, are in higher grade chondrosarcomas and their variants.

References

Feb 11, 1992·Nucleic Acids Research·P V DanenbergJ R Bertino
Apr 1, 1992·Analytical Biochemistry·M E AdamsL J Sandell
Jul 5, 1991·Science·M HollsteinC C Harris
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M OritaT Sekiya
Jun 1, 1995·Human Pathology·B CoughlanH D Dorfman
Feb 1, 1994·Melanoma Research·A P AlbinoN K Hayward
Dec 1, 1993·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Y DobashiR Machinami
Dec 1, 1993·British Journal of Cancer·B WadayamaT Yamamuro
Oct 28, 1993·The New England Journal of Medicine·C C Harris, M Hollstein
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·Y UedaA Roessner
Jul 15, 1995·Cancer·W W SimmsB Czerniak

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Citations

Oct 19, 2006·Skeletal Radiology·W C BellG P Siegal
Aug 17, 2002·Cancer Letters·Tomoki AoyamaJunya Toguchida
Aug 30, 2008·PPAR Research·K NishidaT Ozaki
Mar 16, 2011·Sarcoma·Mi-Jung KimJae Y Ro
Nov 1, 2006·Diagnostic Pathology·John PanelosAnna Batistatou
Jun 17, 2014·Indian Journal of Orthopaedics·Akio Sakamoto
Feb 22, 2012·Pathology Oncology Research : POR·Silvia Calabuig-FariñasAntonio Llombart-Bosch
Aug 24, 2006·Digestive Diseases and Sciences·Vincenzo VillanacciGabrio Bassotti
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xing DaiRajiv Kumar Jha
Feb 14, 2012·Surgical Pathology Clinics·Rajiv Rajani, C Parker Gibbs
Nov 29, 2005·The Orthopedic Clinics of North America·Richard M Terek
Jan 24, 2007·The International Journal of Biochemistry & Cell Biology·Dionysios J Papachristou, Athanasios G Papavassiliou
Aug 20, 2003·Pathology, Research and Practice·M RöpkeR Schneider-Stock
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·J AspP Picci
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A SakamotoM Tsuneyoshi
Dec 22, 1999·Journal of Clinical Pathology·J F Graadt van RoggenP C Hogendoorn
Feb 22, 2012·Virchows Archiv : an International Journal of Pathology·Alessandro FranchiDomenico Campanacci
Feb 21, 2002·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Chuzhao LinRichard M Terek
Dec 13, 2019·Case Reports in Orthopedics·Marine HubyJean-Charles Aurégan
Nov 5, 2020·Archives of Pathology & Laboratory Medicine·Calixto-Hope G LucasAndrew Horvai

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