p53 mutations in classic and pleomorphic invasive lobular carcinoma of the breast.

Cellular Oncology (Dordrecht)
Cigdem ErcanPatrick W B Derksen

Abstract

p53 is a tumor suppressor that is frequently mutated in human cancers. Although alterations in p53 are common in breast cancer, few studies have specifically investigated TP53 mutations in the breast cancer subtype invasive lobular carcinoma (ILC). Recently reported conditional mouse models have indicated that functional p53 inactivation may play a role in ILC development and progression. Since reports on the detection of TP53 mutations in the relatively favorable classic and more aggressive pleomorphic variants of ILC (PILC) are rare and ambiguous, we performed a comprehensive analysis to determine the mutation status of TP53 in these breast cancer subtypes. To increase our understanding of p53-mediated pathways and the roles they may play in the etiology of classic ILC and PILC, we investigated TP53 mutations and p53 accumulation in a cohort of 22 cases of classic and 19 cases of PILC by direct DNA sequencing and immunohistochemistry. We observed 11 potentially pathogenic TP53 mutations, of which three were detected in classic ILC (13.6%) and 8 in PILC (42.1%; p = 0.04). While p53 protein accumulation was not significantly different between classic and pleomorphic ILC, mutations that affected structure and protein function we...Continue Reading

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Citations

Aug 17, 2012·Diagnostic Pathology·Petra Barros dos SantosEduardo I C Beltrão
Aug 21, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Eva VlugPatrick W B Derksen
Sep 24, 2015·Cellular Oncology (Dordrecht)·Cathy B MoelansPatrick W B Derksen
Mar 12, 2015·Breast Cancer Research : BCR·Matthias Christgen, Patrick W B Derksen
Nov 12, 2013·Journal of the Egyptian National Cancer Institute·Heba M ElzawahryNelly H Alieldin
May 29, 2016·Pathology, Research and Practice·Matthias ChristgenHans Kreipe
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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
Mutation Surveyor
HSF
NNSPLICE0

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