PMID: 9180148May 29, 1997Paper

p53 mutations in relation to human papillomavirus type 16 infection in squamous cell carcinomas of the head and neck

International Journal of Cancer. Journal International Du Cancer
A G ScholesJ K Field

Abstract

The relationship between human papillomavirus (HPV) type 16 infection and p53 gene mutations was investigated in squamous cell carcinomas of the head and neck (SCCHN). HPV was detected by general primer-mediated and type-specific PCR. Alterations in the p53 gene were investigated using single-strand conformation polymorphism and sequence analysis in 27 SCCHN, of which 12 were HPV 16-positive and 15 were HPV-negative. Mutations were detected in 2/12 (16.7%) HPV 16-positive and 7/15 (46.7%) HPV-negative tumours; this difference was not statistically significant. The predominant mutations were deletions and C --> T transitions; G --> T transversions were found in only 2 tumours. Our results indicate that the presence of HPV 16 and p53 mutations is not mutually exclusive and detection of a p53 mutation does not exclude a potential role for HPV 16 in the pathogenesis of a subset of SCCHN.

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Citations

Aug 30, 2008·Annual Review of Pathology·Sara I Pai, William H Westra
Jan 24, 2009·Transgenic Research·Rodolfo Ocadiz-DelgadoPatricio Gariglio
Jun 9, 2005·Reviews in Medical Virology·Renwei ChenAntti Vaheri
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Liselotte DahlgrenEva Munck-Wikland
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·V M van HoutenR H Brakenhoff
Sep 12, 2015·Journal of Dental Research·A N PullosC H Squarize
Mar 6, 2018·The American Journal of Surgical Pathology·Deyin XingBrigitte M Ronnett
Mar 24, 2005·Cancer Metastasis Reviews·Zoltán SzentirmayMiklós Kásler
Jun 30, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M BoudaC Kittas
Nov 12, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gayani PitiyageSaman Warnakulasuriya
Sep 5, 2006·Archives of Pathology & Laboratory Medicine·Sigrid Wayne, Robert A Robinson

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