p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers

Oncogene
D W ZhangCaroline G L Lee

Abstract

FAT10 is a member of the ubiquitin-like modifier family of proteins and has been implicated to play important roles in antigen presentation, cytokine response, apoptosis and mitosis. We have recently demonstrated the upregulation of FAT10 gene expression in 90% of hepatocellular carcinoma patients. Here, we identified and characterized the promoter of the FAT10 gene to elucidate the mechanism of FAT10 gene expression. Notably, we found that the 5' untranslated region (5'UTR), from the transcription start site to 15 bases before the translational start site, displays significant promoter activity. Regions upstream of the 5'UTR (from +26 to -1997) do not confer any promoter activity. Curiously, FAT10 promoter activity and expression is significantly repressed in KB3-1 and HepG2 cells, which have wild-type p53, than in p53-negative Hep3B cells. The role of p53 in regulating FAT10 expression was evident by the significant downregulation (P<0.05) of FAT10 mRNA expression and promoter activity when wild-type p53 was transfected into p53-null Hep3B cells. Conversely, inhibiting p53 expression through siRNA against p53 significantly enhanced FAT10 expression and promoter activity. p53 was found to bind in vivo to the 5' half consensus ...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·U M MollA J Levine
Jul 2, 1992·Nature·D P Lane
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B BressacM Ozturk
Oct 27, 1994·Nature·J Pines
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Pagano
Jul 31, 1998·Immunogenetics·P J van den ElsenA Peijnenburg
Jan 16, 1999·Molecular and Cellular Biology·K C LeeM C Barton
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A InnocenteJ M Lee
Apr 2, 1999·Seminars in Cancer Biology·W S el-Deiry
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y C LiuS M Weissman
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C G LeeM M Gottesman
Jul 8, 2000·Trends in Cell Biology·S Jentsch, G Pyrowolakis
Sep 12, 2000·Bone Marrow Transplantation·K van BesienR Hoffman
Oct 18, 2000·The Journal of Biological Chemistry·W R TaylorG R Stark
Dec 1, 2000·Nature·B VogelsteinA J Levine
Mar 27, 2001·Nature Reviews. Molecular Cell Biology·S MüllerS Jentsch
Apr 21, 2001·Oncogene·W R Taylor, G R Stark
Nov 1, 2001·Cell Death and Differentiation·W S El-Deiry
Nov 21, 2001·The Journal of Biological Chemistry·William H HoffmanMaureen Murphy
Feb 12, 2002·Nature Reviews. Molecular Cell Biology·Veronika Jesenberger, Stefan Jentsch
Mar 23, 2002·Science·Thijn R BrummelkampReuven Agami
Apr 2, 2002·Critical Reviews in Immunology·M GroettrupG Schmidtke
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Nov 26, 2002·Oncogene·Ygal HauptVarda Rotter
Dec 26, 2002·Annual Review of Immunology·Attila KumánovicsKirsten Fischer Lindahl
Apr 30, 2003·Cell Death and Differentiation·J Ho, S Benchimol
Jul 2, 2003·Nature Biotechnology·Joseph L Hackett, Lawrence J Lesko
Jul 24, 2003·The Journal of Biological Chemistry·Abel C S Chun, Dong-Yan Jin
Oct 23, 2003·Nature Reviews. Cancer·Thijn R Brummelkamp, René Bernards
Jun 15, 2004·Prostate Cancer and Prostatic Diseases·T M BeerW D Henner

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Citations

Jul 19, 2013·Journal of Proteome Research·Ling LengJian Wang
Mar 10, 2012·Pathology Oncology Research : POR·Jun YuanYongsheng Zhang
Jul 16, 2011·The Journal of Biological Chemistry·Yu NagashimaAtsushi Iwata
Nov 11, 2011·Molecular Biology of the Cell·Samuel BuchsbaumAaron Ciechanover
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Jun 20, 2006·Molecular and Cellular Biology·Allon CanaanSherman M Weissman
Sep 9, 2006·Cell Division·Chuan-Bian LimCaroline G L Lee
Oct 31, 2012·International Journal of Molecular Sciences·Umar-Faruq CajeeMonde Ntwasa
May 14, 2009·World Journal of Gastroenterology : WJG·Feng JiYue-Liang Chen
Jan 21, 2014·Experimental and Molecular Pathology·Jingxiang ChenPing Chen
Mar 15, 2011·Archives of Biochemistry and Biophysics·Tianwei LiP Boon Chock
Oct 5, 2010·Experimental and Molecular Pathology·Xin QingSamuel W French
Jul 6, 2010·Experimental and Molecular Pathology·Joan OlivaSamuel W French
May 4, 2010·Experimental and Molecular Pathology·Joan OlivaSamuel W French
Mar 13, 2010·Experimental and Molecular Pathology·Fawzia Bardag-GorceSamuel W French
Sep 27, 2015·Experimental and Molecular Pathology·Murali GanesanNatalia A Osna
Mar 21, 2008·Trends in Biochemical Sciences·Marcus GroettrupKay Hofmann
Aug 12, 2015·Experimental and Molecular Pathology·Hui LiuSamuel W French
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Bernd FrankHermann Brenner
Dec 9, 2014·Cell Cycle·Martin FischerKurt Engeland
Feb 22, 2012·PloS One·John S BettJacqueline van der Spuy
Oct 6, 2012·Biochemical and Biophysical Research Communications·Samuel BuchsbaumAaron Ciechanover
Aug 30, 2016·Biochemical and Biophysical Research Communications·Chao WuWei Sun
Jun 29, 2018·Genes·Shuaichen LiuCaroline G L Lee
May 15, 2007·Circulation Research·Joerg HerrmannAmir Lerman
May 10, 2019·International Journal of Molecular Sciences·Fengting Wang, Bo Zhao
May 27, 2020·Essays in Biochemistry·Isabelle C Da Costa, Christine K Schmidt
Jun 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanli ZhangChengyu Jiang
Apr 16, 2019·World Journal of Gastrointestinal Oncology·Chun-Yang ZhangXian-Dong Zeng
Sep 19, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kai ZhangLanfang Li

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