PMID: 9175490Apr 1, 1997Paper

P53 overexpression in gastric adenocarcinoma with Helicobacter pylori infection

Yonsei Medical Journal
K H ChangH K Kim

Abstract

Gastric carcinogenesis has been studied in various aspects. Helicobacter pylori (Hp) infection and mutation of the p53 tumor suppressor gene have recently been argued to be important factors of gastric carcinogenesis. There have been many studies to determine the precise mechanism of how Hp is related to gastric cancer, but it is so far still unknown. We studied the relationship of Hp infection and p53 overexpression and tried to discover some significance in clinicopathologic factors such as age, sex, stage, site, differentiation and gross morphology. Ninety-six patients who were diagnosed with gastric cancer at Severance Hospital, Yonsei University Medical College from November 1995 to March 1996, and 96 control patients of non-ulcer dyspepsia (NUD) were studied by endoscopic biopsy of normal gastric tissue and cancer tissue. They also underwent the CLO (Delta West, Melbourne, Western Australia) test for Hp positivity and p53 immunohistochemical stain for p53 positivity. These data were analyzed for comparison with the clinicopathologic characteristics of gastric cancers. In conclusion, the differentiated group cancer had a significantly high Hp positivity and p53 positivity. There is a possibility that Hp infection and p53 t...Continue Reading

Citations

Jun 8, 2010·Journal of Experimental & Clinical Cancer Research : CR·Juan-Bosco Lopez-SaezAvelino Senra-Varela

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
Italo Novoa ReyesElizabeth Refulio Zevallos
© 2021 Meta ULC. All rights reserved