p53, p16 E COX-2 expression in esophageal squamous cell carcinoma and histopathological association

Arquivos De Gastroenterologia
Izabella Paz Danezi FelinAdriana Brondani da Rocha

Abstract

The esophageal carcinoma represents about 2% of malignant tumors and is the third most common cause of gastrointestinal cancer. The correlation between immunohistochemistry markers, such as p53, p16 and COX-2 proteins and cancer esophageal prognosis has been suggested. To Investigate whether the expression of p53, p16 and COX-2 proteins are associated to tumor staging. For this purpose we proceeded immunohistochemistry assays and TMN in 31 esophageal tumor and normal tissue samples. The p53 nuclear expression was considered positive when it appears in 10.00% or more cells. COX-2 expression was scored according to intensity in three scores (1+, 2+, 3+). On the tumor samples the results presented 48.38% positivity for p53, 16.12% for p16 and 100% with 1+, 2+ or 3+ scores for COX-2. However, when we investigated whether the expression of p53, p16 and COX-2 proteins are related to tumor staging, only COX-2 expression, score 3+, had shown statistical significant association. Therefore, in the present study we could see positive correlation between COX-2 protein and high grade tumor as well as advanced tumor staging in esophageal carcinoma.

References

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Citations

Jul 31, 2013·Acta Cirúrgica Brasileira·Antônio Frederico de Freitas GomidesMaria do Carmo Gouveia Peluzio
Sep 3, 2010·Biochemical Genetics·Firouzeh BiramijamalKourosh Shamimi
Feb 18, 2017·Genetics and Molecular Biology·Rodrigo Pinheiro AraldiWilly Beçak
Jul 18, 2021·Environmental Science and Pollution Research International·AbdulRahman A SaiedMohie A M Haridy
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rodrigo Pinheiro AraldiEdislane Barreiros de Souza

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