p53 plays a central role in UVA and UVB induced cell damage and apoptosis in melanoma cells

Cancer Letters
Hong Zhang

Abstract

We investigated whether p53 plays a role in UV induced apoptosis in melanoma. UVA and UVB induced apoptosis in dose dependent and wild type p53 melanoma cells were much more vulnerable than the mutant cells, indicating that p53 played a role in UV-induced apoptosis in melanoma. No difference in p53 expression pattern between the primary and matched metastatic melanomas was noticed in tumour tissue or cell lines from the same patients. Our findings indicate that expression of p53 plays a role in UV-induced apoptosis in melanoma cells, but not important in melanoma progression from primary to metastasis.

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Citations

Sep 29, 2011·Archives of Dermatological Research·Yun Kyung LeeSungkwan An
Nov 13, 2008·Cytotechnology·Nilou Arden, M J Betenbaugh
Jul 1, 2010·The Journal of Biological Chemistry·Jing LinDavid J Weber
Sep 4, 2008·Photochemistry and Photobiology·Juliana Z SandriniLuis F Marins
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Dec 12, 2012·International Journal of Molecular Sciences·Marina T NechiforMircea Leabu
Mar 20, 2009·International Journal of Radiation Biology·Andrew J RidleySarah L Allinson
Apr 21, 2012·Journal of Photochemistry and Photobiology. B, Biology·Marion MillotPatrick Trouillas
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Oct 11, 2008·Expert Review of Dermatology·Brozyna AnnaSlominski Andrzej
Feb 28, 2008·Current Opinion in Oncology

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