PMID: 18212532Jan 24, 2008Paper

P53 promoter selection: choosing between life and death

Cell Cycle
Sanjeev DasSam W Lee

Abstract

A crucial unresolved issue about the genotoxic stress response is how the activation of the p53 tumor suppressor can lead either to cell cycle arrest and DNA repair or to apoptosis. p53 is one of the most important tumor suppressor proteins in the cell to prevent to heritable transfer of damaged DNA. In response to different stress conditions p53 rapidly accumulates and functions as a sequence specific DNA-binding transcription factor to regulate a large number of target genes. Activation of p53 has two major outcomes: cell cycle arrest or apoptosis. In this review we attempt to enumerate the different modifications and co-factors that influence p53 promoter selection and demonstrate how p53 chooses life or death for the cell.

Citations

May 22, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·David Eriksson, Torgny Stigbrand
Sep 25, 2009·Nature Reviews. Cancer·Daniel MenendezMichael A Resnick
Dec 17, 2008·Nature Structural & Molecular Biology·Seong-Yeon ParkV Narry Kim
Aug 12, 2009·Nature Structural & Molecular Biology·Hyonchol JangHong-Duk Youn
Sep 15, 2009·Oncogene·A M Barsotti, C Prives
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sridharan RajagopalanAlan R Fersht
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chao DaiWei Gu
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandre BoyerDerek Boerboom
May 15, 2009·Journal of Carcinogenesis·Mariola KulawiecKeshav K Singh
Jan 25, 2012·Cell and Tissue Research·Simone Di Giovanni, Khizr Rathore
Sep 1, 2008·Expert Opinion on Medical Diagnostics·Mark T Boyd, Nikolina Vlatkovic
Nov 10, 2009·International Journal of Radiation Biology·Yajing LiuAlastair M Thompson
Nov 26, 2008·Toxicology Letters·B Kiran KumarRajanna Bettaiya
Oct 11, 2008·Mutation Research·Luís F Z BatistaCarlos F M Menck
May 29, 2009·Annals of Neurology·Yu LuoYun Wang
Apr 27, 2011·Journal of Cellular Biochemistry·Su-Jung ParkSuk-Hee Lee
Oct 22, 2011·International Journal of Cancer. Journal International Du Cancer·Sin-Ming HuangYi-Ching Wang
May 12, 2010·Journal of Cellular Physiology·Amrita CheemaMaria Laura Avantaggiati
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Elena KashubaGeorge Klein
May 17, 2011·Cell Cycle·Peter AndorferHans Rotheneder
Oct 16, 2010·Cell Cycle·Katharina SchlerethThorsten Stiewe
Mar 4, 2010·Biophysical Journal·Ingunn W JolmaPeter Ruoff
Jul 29, 2016·Journal of Cellular and Molecular Medicine·Laurent Ah-KoonOlivier Schischmanoff
Nov 2, 2017·Interdisciplinary Sciences, Computational Life Sciences·Malathi Shekar, Moleyur Nagarajappa Venugopal
Feb 9, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Franck MeslinSalem Chouaib
Aug 7, 2014·International Journal of Oncology·See-Hyoung ParkMickey C-T Hu
Jul 28, 2016·Oncotarget·Nir DraymanAriella Oppenheim
Feb 9, 2018·Oncotarget·Gaetano FacchiniMicaela Montanari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis