p53 protein accumulation predicts poor response to tamoxifen therapy of patients with recurrent breast cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
E M BernsJ A Foekens

Abstract

Mutations of the p53 gene are frequently observed in primary breast cancer and accumulation of p53 protein has been used as a surrogate marker of p53 inactivation. Previous studies have shown that p53 accumulation is related to poor prognosis in primary breast cancer. We studied whether p53 protein accumulation is a predictive factor for response to tamoxifen treatment in patients with recurrent breast cancer. Levels of p53, estrogen receptor (ER), progesterone receptor (PgR), and urokinase-type plasminogen activator (uPA) were assayed in cytosolic extracts derived from primary tumors of 401 tamoxifen-naive patients who developed recurrent disease. All patients in the study received tamoxifen therapy upon relapse (median follow-up, 69 months). Association of tested factors with response to tamoxifen treatment was studied by logistic regression analysis, and with survival after the start of treatment by Cox univariate and multivariate regression analysis. p53 levels (median, 0.23 ng/mg protein) were not related to ER or PgR levels, but positively correlated with uPA (P < .0001). In a test for trend, we observed an association of p53 protein levels with response to tamoxifen therapy. When dichotomized (at the median value), 42% i...Continue Reading

Citations

Nov 6, 2001·Drugs·L C DorssersJ A Foekens
Aug 13, 2010·Biomarkers in Medicine·Rudolf NapieralskiManfred Schmitt
Jul 29, 2011·Annals of the New York Academy of Sciences·Dong Hoon SuhYong Sang Song
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Pankaj SinghalKunle Odunsi
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura HavrileskyUNKNOWN Gynecologic Oncology Group Study
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S KnoopC Rose
Oct 23, 2014·Journal of Cancer Prevention·Dong Hoon SuhYong Sang Song
Jul 2, 1999·Journal of Surgical Oncology·M J DuffyN O'Higgins
Mar 5, 1999·Breast Cancer Research and Treatment·R M Elledge, D C Allred
Aug 16, 2017·Cancer Cell·Lucy R YatesPeter J Campbell
Oct 13, 1998·Cancer Treatment Reviews·G Y Locker
Oct 27, 2004·Critical Reviews in Oncology/hematology·Anis Feki, Irmgard Irminger-Finger
Mar 20, 2002·Clinical Breast Cancer·J Geisler, P E Lønning

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