PMID: 9658131Jul 11, 1998Paper

p53 protein is a suppressor of papillomavirus DNA amplificational replication

Journal of Virology
D LepikMart Ustav

Abstract

p53 protein was able to block human and bovine papillomavirus DNA amplificational replication while not interfering with Epstein-Barr virus oriP once-per-cell cycle replication. Oligomerization, intact DNA-binding, replication protein A-binding, and proline-rich domains of the p53 protein were essential for efficient inhibition, while the N-terminal transcriptional activation and C-terminal regulatory domains were dispensable for the suppressor activity of the p53 protein. The inhibition of replication was caused neither by the downregulation of expression of the E1 and E2 proteins nor by cell cycle block or apoptosis. Our data suggest that the intrinsic activity of p53 to suppress amplificational replication of the papillomavirus origin may have an important role in the virus life cycle and in virus-cell interactions.

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Citations

May 27, 2015·Viruses·Caleb C McKinneyAlison A McBride
Aug 12, 1999·Annals of Medicine·S M Syrjänen, K J Syrjänen
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J Courcelle, P C Hanawalt
Jun 18, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Louise T ChowBettie M Steinberg
Apr 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Eun-Young KhoLouise T Chow
May 23, 2008·Journal of Virology·Shih-Shin ChangChing-Hwa Tsai
Jun 21, 2013·Journal of Virology·Yuhei MaruzuruYasushi Kawaguchi
Mar 14, 2000·Seminars in Cancer Biology·F Mantovani, L Banks

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