p53 Status correlates with the risk of recurrence in non-muscle invasive bladder cancers treated with Bacillus Calmette-Guérin: a meta-analysis

PloS One
Xiaofeng ZhouYe Tian

Abstract

Published studies have yielded inconsistent results on the relationship between p53 status and the prognosis of non-muscle invasive bladder cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG) intravesical therapy. Therefore, we performed a meta-analysis to evaluate the prognostic value of p53 in NMIBC treated with BCG. We systematically searched for relevant literature in PubMed, EMBASE, CNKI, and Chinese Wanfang databases. Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined as the effect size (ES) across studies for recurrence-free survival (RFS) and progression-free survival (PFS). A total of 11 studies, consisting of 1,049 participants, met the criteria. Overall, there was no clear relationship between p53 status and RFS or PFS for NMIBC patients treated with BCG (HR: 1.40, 95% CI: 0.91-2.16; HR: 1.37, 95% CI: 0.90-2.09, respectively). Obvious heterogeneity was observed across the studies (I2 = 69.5%, P = 0.001; I2 = 44.7%, P = 0.081, respectively). In stratified analysis by region, p53 overexpression was a predictor of poor RFS in Asian populations (HR: 1.57, 95% CI: 1.08-2.27). In addition, after excluding the studies that possibly contributed to the heterogeneity by the Galbraith plot, the overall...Continue Reading

References

Jul 23, 1992·The New England Journal of Medicine·J LauT C Chalmers
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L LacombeV E Reuter
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·E LeeC Lee
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe
Sep 1, 2005·The Lancet Oncology·Núria MalatsFrancisco X Real
Dec 10, 2008·American Journal of Epidemiology·Leon BaxKarel G M Moons
Feb 17, 2009·World Journal of Urology·Martine PloegLambertus A Kiemeney
Jan 26, 2011·The Journal of Cell Biology·Patricia A J MullerJim C Norman
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Aug 31, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yanlei MaHuanlong Qin
Sep 9, 2011·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Zana DolićaninVesna Marjanović
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Ting XuXin-En Huang
Sep 18, 2012·European Urology·Maximilian BurgerUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Oct 30, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M JinK Chen
Feb 22, 2013·Current Opinion in Oncology·Matthew J ResnickPeter E Clark
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology
Feb 13, 2014·European Journal of Nutrition·Xin XuLiping Xie
Sep 24, 2014·BMC Medical Research Methodology·Miriam Gjerdevik, Ivar Heuch

❮ Previous
Next ❯

Citations

Jul 28, 2019·Pathology Oncology Research : POR·Rafał StecAleksandra Semeniuk-Wojtaś
Sep 28, 2018·World Journal of Urology·Francesco SoriaShahrokh F Shariat
Apr 28, 2021·Cellular Oncology (Dordrecht)·Yafei YangJun Pang

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.