P53: The endothelium defender

Journal of Cellular Biochemistry
Mohammad Afaz Uddin, Nektarios Barabutis

Abstract

P53 represents the paradigm of a multitalented transcription factor, responsible for the cellular defense against a plethora of potentially harmful stimuli. It exercises the ability to strongly oppose both cancer and inflammation, partially due to the fact that both conditions are highly interrelated. Endothelium hyperpermeability is considered the hallmark of severe lung inflammation, and the cardinal feature of the lethal acute respiratory distress syndrome. An emerging body of evidence suggests a strategic role of P53 towards vascular barrier integrity. The "endothelium defender" orchestrates meticulously devised responses; to counteract toxin-induced destructions of endothelium monolayers. The present effort seeks to further our understanding on the expanding P53 universe, discussing the most recent information regarding the involvement of that molecule in the pulmonary function.

References

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Jun 4, 2010·Journal of Cellular and Molecular Medicine·Nektarios BarabutisAndrew V Schally
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Apr 16, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nektarios BarabutisJohn D Catravas
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Nov 3, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nektarios BarabutisJohn D Catravas
Jul 25, 2017·The Journal of Allergy and Clinical Immunology·Peng WangYong Zhao
Dec 12, 2017·Cell Death and Differentiation·Arnold J Levine
Jan 25, 2018·Journal of Cellular and Molecular Medicine·Nektarios BarabutisJohn D Catravas
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Nov 10, 2018·Seminars in Immunology·Barbara BottazziAlberto Mantovani
Nov 14, 2018·Cytokine·Nektarios BarabutisJohn D Catravas
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Jan 1, 2018·Cell Death and Differentiation·Arnold J Levine

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Citations

Jul 25, 2019·Journal of Biochemical and Molecular Toxicology·Mohammad S AkhterNektarios Barabutis
Dec 28, 2019·Cell Cycle·Khadeja-Tul KubraNektarios Barabutis
Feb 28, 2020·Cytoskeleton·Nektarios Barabutis
Apr 14, 2020·Cell Biology International·Nektarios Barabutis, Agnieszka Siejka
Apr 15, 2020·Clinical and Experimental Pharmacology & Physiology·Nektarios Barabutis
Sep 5, 2020·Cellular and Molecular Life Sciences : CMLS·Nektarios Barabutis
Aug 28, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Khadeja-Tul KubraNektarios Barabutis
Oct 4, 2019·Tissue Barriers·Mohammad A UddinNektarios Barabutis
Aug 28, 2020·Frontiers in Medicine·Nektarios Barabutis
Dec 16, 2019·Inflammation·Mohammad S AkhterNektarios Barabutis
Jun 28, 2020·Cellular Signalling·Khadeja-Tul KubraNektarios Barabutis
Dec 15, 2019·Cellular Signalling·Khadeja-Tul KubraNektarios Barabutis
Apr 3, 2021·Endocrine and Metabolic Science·Nektarios Barabutis
Apr 27, 2019·Immunobiology·Mohammad A UddinNektarios Barabutis

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