P53 tumour suppressor gene and germ cell neoplasia

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
S G Lutzker

Abstract

P53 tumour suppressor gene mutations occur in approximately 50% of common solid tumours such as breast, colon and lung. In contrast, p53 gene mutations occur infrequently (< 3%) in germ cell tumours, even though p53 protein is expressed at high levels in the vast majority of tumour samples. P53-regulated genes are not correspondingly over-expressed in germ cell tumour samples and cell lines, indicating that p53 functions poorly as a transcription factor in this tumour type. High levels of wild-type p53 may contribute, in part, to the chemosensitivity of germ cell tumours.

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·U M MollA J Levine
Sep 9, 1991·International Journal of Cancer. Journal International Du Cancer·J BártkováD P Lane
Oct 1, 1990·International Journal of Andrology·H TeschD L Bronson
Apr 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C N ParrisJ R Masters
Dec 1, 1983·Molecular and Cellular Biology·N C ReichA J Levine
Dec 1, 1984·Cell Differentiation·L C Stevens
Jun 1, 1995·Nature Genetics·V P SahT Jacks
Feb 1, 1993·Genes, Chromosomes & Cancer·K HeimdalA L Børresen
Mar 1, 1995·Genes & Development·C E CanmanM B Kastan
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·U M MollG Riou
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·H Lu, A J Levine
Mar 1, 1995·Molecular Carcinogenesis·G RiouA J Levine
Nov 4, 1994·Science·S W LoweT Jacks
Jul 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M HarveyL A Donehower
Apr 1, 1993·Genes & Development·M Debbas, E White
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V RotterA J Levine
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·J R MastersC N Parris
May 1, 1996·Nature Medicine·T NorimuraS Kondo
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A Hickman
Jan 1, 1996·Cancer Treatment and Research·S G Lutzker, A J Levine

❮ Previous
Next ❯

Citations

May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ewa Rajpert-De MeytsNiels E Skakkebaek
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E Rajpert-De MeytsN E Skakkebaek
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
May 23, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jirina BartkovaJiri Bartek
Jan 5, 2002·Cancer Investigation·K A McGlynn
Apr 7, 2010·The Lancet Oncology·Tarinee ManchanaJohn J Kavanagh
May 20, 2003·The Journal of Pathology·Diana C J SpieringsSteven de Jong
May 12, 2001·American Journal of Obstetrics and Gynecology·A NawaN Nakashima
Nov 5, 2013·Critical Reviews in Oncology/hematology·Ludmila BoublikovaJan Trka
Jul 30, 2014·Seminars in Cancer Biology·Martin A Rijlaarsdam, Leendert H J Looijenga
May 4, 1999·International Journal of Cancer. Journal International Du Cancer·H BurgerG Stoter
Sep 2, 2016·Current Opinion in Urology·Solomon L WolduAditya Bagrodia
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Madhu MazumdarGeorge J Bosl
Dec 11, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F SelleJ P Lotz
Nov 9, 2016·Oncotarget·Francesco Jacopo RomanoGaetano Facchini
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·M RørthN E Skakkebaek
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·K P Dieckmann, N E Skakkebaek
Oct 16, 2012·Virchows Archiv : an International Journal of Pathology·Z BingJ E Tomaszewski
Jun 3, 2021·International Journal of Molecular Sciences·Dennis M TimmermanLeendert H J Looijenga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.