PMID: 7515496Jun 7, 1994Paper

p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation

Proceedings of the National Academy of Sciences of the United States of America
C CoutureT Mustelin

Abstract

Activation of resting T lymphocytes by ligands to the T-cell antigen receptor (TCR)/CD3 complex is initiated by rapid tyrosine phosphorylation of cellular proteins. Protein-tyrosine kinases (PTKs) of the src family are known to be important, but the mechanism of their recruitment and their interactions with PTKs of other families are incompletely understood. We show that a member of another family of PTKs, the p72syk kinase, is constitutively bound to the TCR/CD3 complex and becomes tyrosine phosphorylated and activated within 1 min after TCR/CD3 stimulation. This activation did not depend on the presence of p56lck in T cells and in transfected COS cells. In both cases, however, the phosphorylation of cellular substrates was augmented by src family PTKs. We propose that p72syk may act as an immediate receptor-activated kinase upstream of the related p70zap PTK and the src family PTKs p56lck and p59fyn in T cells and that these src family PTKs act as signal amplifiers.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A D BeyersA F Williams
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J E HutchcroftJ M Oliver
May 14, 1992·Nature·T J MolinaA Veillette
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A C ChanA Weiss
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C H JuneL E Samelson
Jun 1, 1993·Trends in Biochemical Sciences·T Mustelin, P Burn
Jul 16, 1993·Cell·W KolanusB Seed

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Citations

Aug 24, 1999·European Journal of Immunology·J BrockdorffT Mustelin
Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G ZennerT Mustelin
Sep 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J H HankeP S Changelian
Apr 1, 1995·Current Opinion in Cell Biology·A L DeFranco
Jun 6, 2000·Advanced Drug Delivery Reviews·Z Eshhar, C J Fitzer-Attas
Jun 1, 1996·Current Opinion in Immunology·A C Chan, A S Shaw
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S P SidorenkoE A Clark
Feb 1, 1996·The Journal of Experimental Medicine·D QianA Weiss
Jan 1, 1997·Annual Review of Immunology·M Reth, J Wienands
Feb 12, 1998·The Journal of Experimental Medicine·K M BrumbaughP J Leibson
Oct 1, 1994·Current Opinion in Cell Biology·S J ShattilJ S Brugge
Mar 5, 2010·The Journal of General Psychology·Stephen RiceJoshua Sandry
Mar 28, 1997·The Journal of Biological Chemistry·C J Fitzer-AttasZ Eshhar
Feb 10, 1995·The Journal of Biological Chemistry·R WeilA Veillette
Aug 5, 2018·Journal of Cellular Physiology·Alexander Y Tsygankov
Aug 1, 1997·European Journal of Immunology·D L FarberK Bottomly

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