PMID: 9658338Jul 11, 1998Paper

p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway

Journal of Neurobiology
W R MorseP F Maness

Abstract

The Src-family tyrosine kinases p59fyn and pp60c-src are localized on axons of the mouse olfactory nerve during the initial stages of axonal growth, but their functional roles remain to be defined. To study the role of these kinases, we analyzed the trajectory of the olfactory nerve in E11.5 homozygous null mutant mice lacking single src or fyn gens and double mutants lacking both genes. Primary olfactory axons of single and double mutants exited the olfactory epithelium and projected toward the telencephalon, but displayed differences in fasciculation. The fyn-minus olfactory nerve had significantly more fascicles than than src-minus nerve. Most strikingly, the primary olfactory nerve of src/fyn double mutants showed the greatest degree of defasciculation. These defects, identified by NCAM labeling, were not due to apparent changes in the size of the olfactory epithelium. With the exception of the src-minus mice, which had fever fascicles than the wild type, no obvious differences were observed in coalescence of vomeronasal axons from mutant mice. The mesenchyme of the double and single mutants exhibited only subtle changes in laminin and fibronectin staining, indicating that the adhesive environment of the mesenchyme may cont...Continue Reading

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Citations

Jan 29, 2000·Journal of Neuroscience Research·J C MorganD S Galileo
Mar 4, 2006·Journal of Molecular Histology·Fatemeh ChehrehasaBrian Key
Feb 15, 2001·Brain Research. Developmental Brain Research·G P DemyanenkoP F Maness
May 2, 2002·The European Journal of Neuroscience·Nicole SalèsKenneth L Moya
Aug 22, 2008·Molecular Biology of the Cell·Bingbing WuDaniel M Suter
Feb 27, 2013·Molecular and Cellular Biology·Margaret Chui Ling TseChi Bun Chan
Feb 18, 2010·The Journal of Clinical Investigation·Ryoichi BannoKendra K Bence
Dec 3, 2014·Brain Research·M Iqbal HossainHeung-Chin Cheng
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Nov 15, 2002·Developmental Cell·Shiro SuetsuguTadaomi Takenawa
Jun 14, 2002·Developmental Cell·William E LowryXin-Yun Huang
Mar 10, 2004·Journal of Neurobiology·Eric V WongDaniel G Jay
Apr 6, 2004·The Journal of Comparative Neurology·Curtis William Balmer, Anthony-Samuel LaMantia
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Aug 5, 2003·The Journal of Comparative Neurology·James A St JohnBrian Key
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Oct 3, 2002·Molecular and Cellular Neurosciences·Diane Hoffman-KimDaniel G Jay
Feb 1, 2005·The Journal of Comparative Neurology·Tun-Tzu YuTimothy S McClintock

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