p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor

Cell Proliferation
Jing ZhangLei Dong

Abstract

The role of p62 in cancer is controversial. Evidence has shown that p62 is upregulated in different cancers and promotes tumour growth, such as in liver cancer and lung cancer. However, a recent study showed that the downregulation of p62 in hepatic stellate cells (HSCs) promotes hepatocellular carcinoma (HCC) development. How p62 is regulated in colorectal cancer (CRC) remains largely unknown. In this study, we aimed to investigate the roles and molecular mechanisms of p62 in CRC. The expression levels of p62 in CRC tissues and adjacent non-tumour tissues were determined by immunohistochemistry (IHC). Stable p62-overexpression HCT116 cells and p62-knockdown SW480 cells were established with lentiviral vectors. The role of p62 in CRC was investigated in in vitro and in vivo functional studies. The relationship between p62 and the vitamin D receptor (VDR) was investigated by coimmunoprecipitation (Co-IP) assays. p62 was significantly upregulated in CRC, and a high p62 level was an independent risk factor for a poor prognosis in CRC patients. p62 promoted CRC migration and invasion by inhibiting apoptosis and promoting cell proliferation in vitro, and p62 aggravated tumour growth and metastasis in vivo. Co-IP assays indicated tha...Continue Reading

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Citations

Jul 28, 2020·Pharmaceuticals·Angel Escamilla-RamírezCristina Trejo-Solís
Feb 27, 2021·Frontiers in Oncology·Cristóbal Cerda-TroncosoPatricia V Burgos
Mar 26, 2021·Frontiers in Oncology·Alejandra SuaresOmar Coso
Aug 28, 2021·Journal of Cellular Physiology·Prashant KumarAmit Mishra
Oct 7, 2021·Autophagy·Yinfeng XuWei Wan

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Methods Mentioned

BETA
ubiquitination
PCR
flow cytometry
xenograft
xenografts

Software Mentioned

GeneGnome XRQ
graphpad prism

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