p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases

Brain Sciences
Artem P GureevVasily N Popov

Abstract

Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway, which is involved in the regulation of the expression of genes responsible for oxidative stress protection, regulation of mitochondrial biogenesis, and mitophagy. The p62 protein is a multifunctional cytoplasmic protein that functions as a selective mitophagy receptor for the degradation of ubiquitinated substrates. There is evidence that p62 can positively regulate Nrf2 by binding to its negative regulator, Keap1. However, there is also strong evidence that Nrf2 up-regulates p62 expression. Thereby, a regulatory loop is formed between two important signaling pathways, which may be an important target for drugs aimed at treating neurodegeneration. Constitutive activation of p62 in parallel with Nrf2 would most likely result in the activation of mTORC1-mediated signaling pathways that are associated with the development of malignant neoplasms. The purpose of this review is to describe the p62-Nrf2-p62 regulatory loop and to evaluate its role in the regulation of mitophagy under variou...Continue Reading

References

Mar 19, 2008·Journal of Neurochemistry·J Ramesh BabuMarie W Wooten
Jan 26, 2010·Nature Cell Biology·Sven GeislerWolfdieter Springer
Apr 10, 2010·The Journal of Biological Chemistry·Ian M CoppleB Kevin Park
Dec 1, 2010·The Journal of Cell Biology·Seok Min JinRichard J Youle
Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Richard J Youle, Derek P Narendra
Apr 13, 2011·The Journal of Cell Biology·Yoshihiro InamiMasaaki Komatsu
May 19, 2011·Biochemistry. Biokhimii︠a︡·V O TkachevN K Zenkov
Jul 6, 2011·The Biochemical Journal·Martin D Brand, David G Nicholls
Oct 11, 2011·Molecular Cell·Angeles DuranMaria T Diaz-Meco
Nov 1, 2011·Free Radical Biology & Medicine·Hilla ErlankJoseph Kanner
Dec 4, 2012·Free Radical Biology & Medicine·Michael H YanXiongwei Zhu
Feb 13, 2013·Sub-cellular Biochemistry·Arthur I Cederbaum
Feb 14, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Juan A MarchalMaria A Garcia
Mar 19, 2014·Genes & Development·Tongde WuDonna D Zhang
Jul 12, 2014·BioMed Research International·Mónika Lippai, Péter Lőw
Dec 3, 2014·Chemistry & Biology·Daniel A EastMichelangelo Campanella
Jun 15, 2012·Neural Regeneration Research·Xianhong ZhengLiankun Sun
May 16, 2015·Free Radical Biology & Medicine·Albena T Dinkova-Kostova, Andrey Y Abramov
Jun 7, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yu ZouMiaoxian Dong
Jun 9, 2015·Biochimica Et Biophysica Acta·Brendan A I Payne, Patrick F Chinnery
Aug 11, 2015·Cell Death and Differentiation·K PalikarasN Tavernarakis
Aug 14, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Denis N SilachevDmitry B Zorov

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Citations

Feb 14, 2021·Cells·Sara Marmolejo-Martínez-ArteseroDavid Romeo-Guitart

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Methods Mentioned

BETA
ubiquitination

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