p63 Expression in the Gerbil Hippocampus Following Transient Ischemia and Effect of Ischemic Preconditioning on p63 Expression in the Ischemic Hippocampus

Neurochemical Research
Jae-Chul LeeHui Young Lee

Abstract

p63 is a transcription factor of p53 gene family, which are involved in development, differentiation and cell response to stress; however, its roles in ischemic preconditioning (IPC) in the brain are not clear. In the present study, we investigated the effect of IPC on p63 immunoreactivity caused by 5 min of transient cerebral ischemia in gerbils. IPC was induced by subjecting the gerbils to 2 min of transie ischemia 1 day prior to 5 min of transient ischemia. The animals were randomly assigned to four groups (sham-operated-group, ischemia-operated-group, IPC plus (+)-sham-operated-group and IPC + ischemia-operated-group). The number of viable neurons in the stratum pyramidale of the hippocampal CA1 region (CA1) was significantly increased by IPC + ischemia-operated-group compared with that in the ischemia-operated-group 5 days after ischemic insult. We found that strong p63 immunoreactivity was detected in the CA1 pyramidal neurons in the sham-operated-group, and the immunoreactivity was decreased with time after ischemia-reperfusion. In addition, strong p63 immunoreactivity was newly expressed in microglial cells of the CA1 region from 2 days after ischemia-reperfusion. In all the IPC + sham-operated-groups, p63 immunoreactiv...Continue Reading

References

Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NedergaardN H Diemer
Jan 1, 1984·Acta Neuropathologica·T Kirino, K Sano
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Feb 7, 1998·The Journal of Biological Chemistry·M L AgarwalG R Stark
May 26, 1999·The Journal of Pathology·C Prives, P A Hall
Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·M WeihK M Einhäupl
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SuzukiY Fukuuchi
Jun 14, 2000·Neurology·J MoncayoG van Melle
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P H Chan
Mar 30, 2001·Cell Death and Differentiation·R S Morrison, Y Kinoshita
Mar 30, 2001·Cell Death and Differentiation·F D MillerG S Walsh
Jun 10, 2005·The EMBO Journal·Olav GressnerMartina Müller
Dec 13, 2005·Neuron·W Bradley JacobsDavid R Kaplan
Jun 30, 2006·Journal of Neurochemistry·W Bradley JacobsFreda D Miller
Mar 14, 2008·Neurochemical Research·Małgorzata BeresewiczBarbara Zabłocka
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jan LehotskýBeata Saniová
Jul 3, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Takayuki NakajimaKazushige Ogawa
Mar 24, 2011·Nature Reviews. Molecular Cell Biology·Arnold J LevineGerry Melino
Jul 16, 2011·Cell Death and Differentiation·G Melino

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Citations

Jun 24, 2016·Neural Regeneration Research·Yan-Zhen ZhuBing Wu
Apr 8, 2020·Laboratory animal research·Tae-Kyeong LeeJi Hyeon Ahn

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