p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival

Virchows Archiv : an International Journal of Pathology
Philip J CoatesBorivoj Vojtesek

Abstract

The TP63 gene encodes two major protein variants that differ in their N-terminal sequences and have opposing effects. In breast, ΔNp63 is expressed by immature stem/progenitor cells and mature myoepithelial/basal cells and is a characteristic feature of basal-like triple-negative breast cancers (TNBCs). The expression and potential role of TAp63 in the mammary gland and breast cancers is less clear, partly due to the lack of studies that employ p63 isoform-specific antibodies. We used immunohistochemistry with ΔNp63-specific or TAp63-specific monoclonal antibodies to investigate p63 isoforms in 236 TNBCs. TAp63, but not ΔNp63, was seen in tumour-associated lymphocytes and other stromal cells. Tumour cells showed nuclear staining for ΔNp63 in 17% of TNBCs compared to 7.3% that were positive for TAp63. Whilst most TAp63+ tumours also contained ΔNp63+ cells, the levels of the two isoforms were independent of each other. ΔNp63 associated with metaplastic and medullary cancers, and with a basal phenotype, whereas TAp63 associated with androgen receptor, BRCA1/2 wild-type status and PTEN positivity. Despite the proposed effects of p63 on proliferation, Ki67 did not correlate with either p63 isoform, nor did they associate with p53 mu...Continue Reading

References

Nov 16, 2002·The Journal of Pathology·Karin NylanderPhilip J Coates
Jun 1, 2005·Mechanisms of Development·Takeshi KuritaRoanna T Medina
May 26, 2006·European Journal of Human Genetics : EJHG·Tuula RinneHans van Bokhoven
Apr 21, 2007·The Journal of Clinical Investigation·Chee-Onn LeongLeif W Ellisen
Jul 3, 2009·Cell Stem Cell·Xiaohua SuElsa R Flores
Oct 27, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aye Aye ThikePuay Hoon Tan
Nov 10, 2009·Nature Cell Biology·Xuecui GuoAlea A Mills
Jan 19, 2010·Annual Review of Pathology·Christopher P Crum, Frank D McKeon
Mar 13, 2010·Virchows Archiv : an International Journal of Pathology·Dario de BiaseVincenzo Eusebi
Apr 10, 2010·Cell Death and Differentiation·O Yalcin-OzuysalC Brisken
Jan 26, 2011·The Journal of Cell Biology·Patricia A J MullerJim C Norman
Mar 29, 2011·Cellular & Molecular Biology Letters·Marta NekulovaBorivoj Vojtesek
Nov 8, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Justin A BishopNatasha Rekhtman
Oct 9, 2012·Cell Metabolism·Xiaohua SuElsa R Flores
Jul 28, 2013·Virchows Archiv : an International Journal of Pathology·Marta NekulovaBorivoj Vojtesek
Oct 12, 2013·The Journal of Pathology·Brian D Lehmann, Jennifer A Pietenpol
Jul 17, 2014·The American Journal of Surgical Pathology·Samuel A HendersonMichael T Tetzlaff
Sep 6, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marie-Christine AubryAndrew L Feldman
Nov 25, 2014·Oncogene·M H StindtK H Vousden
Apr 9, 2015·Virchows Archiv : an International Journal of Pathology·Verena SailerGlen Kristiansen
Jan 31, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Paulina OrzolPhilip J Coates
Sep 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kathryn E YohRon Prywes
Mar 30, 2017·Breast Cancer Research and Treatment·Jitka HolcakovaPhilip J Coates
May 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Linshan HuZhi-Xiong Jim Xiao

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Citations

May 10, 2019·Cancers·Feda H Hamdan, Steven A Johnsen
Jun 25, 2020·Cancer Metastasis Reviews·Belinda J Petri, Carolyn M Klinge
Oct 11, 2020·Virchows Archiv : an International Journal of Pathology·Michaela GaloczovaPhilip J Coates
Feb 28, 2021·The Journal of Pathology·Zuzana PokornáPhilip J Coates

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