PMID: 11323391Apr 27, 2001Paper

p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas

Carcinogenesis
A K El-NaggarG Lozano

Abstract

p73, a recently identified gene, maps to chromosome region 1p36.3, which is frequently deleted in a variety of solid tumors. Although the gene shares sequence and functional homologies with p53, its suppressor function has not been proven. We investigated for the first time the genetic and expression status of the p73 gene and analyzed its flanking microsatellite loci on chromosome 1p36.3 in 67 primary oral and laryngeal squamous cell carcinomas to determine their association with these tumors. Our results reveal two missense mutations at codons 469 and 477 and a silent mutation at codon 349 in the C-terminal domain. Site-directed mutagenesis of p73 cDNA with these mutations and a p21 transactivation assay failed to show any significant functional consequences of these mutations. Microsatellite analysis of the flanking loci of p73 in region 1p36 showed overall alterations (loss of heterozygosity and instability) frequency of 39%, 16% at the proximal marker and 46% at the distal markers. Of the 21 cases for which we did protein expression analyses, 11 tumors had a >2-fold variation compared with matching histologically normal mucosa. Our study shows that: (i) intragenic alterations in this gene are rare and lack functional signi...Continue Reading

Citations

Oct 19, 2011·Journal of Nucleic Acids·Jinxiong WeiAlexander Zaika
May 31, 2012·Journal of Oncology·Thian-Sze WongWai-Kuen Ho
Feb 11, 2009·Molecular Carcinogenesis·Chaitali MisraSusanta Roychoudhury
Mar 28, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mathieu LefeuvreNoriyuki Nagai
Aug 14, 2008·Journal of Cutaneous Pathology·Si-Yuan ChenYoichi Moroi
Jul 30, 2014·Molecular and Cellular Biology·Neelam Chaudhary, Subbareddy Maddika
Dec 26, 2001·Cell Death and Differentiation·T J GrobA Tobler
Mar 1, 2005·The Journal of Biological Chemistry·Wen Hong TohKanaga Sabapathy

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