PMID: 11897798Mar 19, 2002Paper

p73 is expressed in human thymic epithelial cells

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Shingo IchimiyaNoriyuki Sato

Abstract

The thymus is a heterogeneous immune organ in which immature T-cells develop and eventually specialize to make certain immune responses of their own. Among various types of stromal cells in the thymus, thymic epithelial cells (TECs) have a crucially important function for presenting self-antigens and secreting cytokines to thymocytes for their maturation into T-cells. In this study we show that the p73 gene, a homologue of the tumor suppressor gene p53, was expressed in the nucleus of the human TEC in vivo and in TEC lines in vitro. Because p73 has the capacity to be a transactivator like p53, it may contribute to T-cell development in the context of TEC biology as regulated in the cell cycle and apoptosis.

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Citations

Feb 6, 2004·Brain Tumor Pathology·Hiroyuki MomotaNoriyuki Sato
Mar 27, 2007·Journal of Molecular Histology·Seung-Mo HongAlexander I Zaika
Oct 8, 2004·Archives of Histology and Cytology·Tatsuya IrifuneTetsuo Fukumoto
Mar 22, 2015·Clinical and Experimental Medicine·Alexandra Papoudou-BaiPanagiotis Kanavaros
Aug 23, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo Ichimiya, Takashi Kojima

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