p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells

Biochemical and Biophysical Research Communications
Y UedaK Shimotohno

Abstract

The Wnt/beta-catenin pathway and p53 are very common targets for genetic alterations in colorectal cancer, and relationships between them have been reported. Here, we describe the relation between Wnt/beta-catenin signaling and the p53-related gene p73. p73, but not p53, activated a promoter containing the Tcf-binding sequence in Saos-2 cells, and the degree of activation was positively correlated with that on a p53-responsive promoter. Moreover, p73beta enhanced Wnt/beta-catenin signaling synergistically with Wnt-3a or exogenously expressed beta-catenin, unlike p53, and the enhancement was not caused by the accumulation of beta-catenin. These results show that the effects of p73 on Wnt/beta-catenin signaling differ from those of p53.

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Citations

Jun 25, 2005·Biochemical and Biophysical Research Communications·Eliana MunarrizPierluigi Nicotera
Dec 25, 2004·Brain Research. Developmental Brain Research·Takashi IriokaYoshiki Sasai
Aug 13, 2015·Molecular Neurobiology·Maria Victoria Niklison-ChirouMassimiliano Agostini
Dec 4, 2003·Oncogene·Apollonia TulloElisabetta Sbisà
Aug 3, 2002·Nature Reviews. Cancer·Gerry MelinoKaren H Vousden
Apr 5, 2005·The Journal of Biological Chemistry·Zubaida SaifudeenSamir S El-Dahr
Feb 26, 2008·Molecular Cancer Research : MCR·Yasushi SasakiTakashi Tokino
Sep 24, 2005·Journal of Cell Science·Yasuo OuchiSumiko Watanabe

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