p75NTR expression in rat urinary bladder sensory neurons and spinal cord with cyclophosphamide-induced cystitis

The Journal of Comparative Neurology
Mary Beth KlingerM A Vizzard

Abstract

A role for nerve growth factor (NGF) in contributing to increased voiding frequency and altered sensation from the urinary bladder has been suggested. Previous studies have examined the expression and regulation of tyrosine kinase receptors (Trks) in micturition reflexes with urinary bladder inflammation. The present studies examine the expression and regulation of another receptor known to bind NGF, p75(NTR), after various durations of bladder inflammation induced by cyclophosphamide (CYP). CYP-induced cystitis increased (P < or = 0.001) p75(NTR) expression in the superficial lateral and medial dorsal horn in L1-L2 and L6-S1 spinal segments. The number of p75(NTR)-immunoreactive (-IR) cells in the lumbosacral dorsal root ganglia (DRG) also increased (P < or = 0.05) with CYP-induced cystitis (acute, intermediate, and chronic). Quantitative, real-time polymerase chain reaction also demonstrated significant increases (P < or = 0.01) in p75(NTR) mRNA in DRG with intermediate and chronic CYP-induced cystitis. Retrograde dye-tracing techniques with Fastblue were used to identify presumptive bladder afferent cells in the lumbosacral DRG. In bladder afferent cells in DRG, p75(NTR)-IR was also increased (P < or = 0.01) with cystitis. I...Continue Reading

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Citations

May 8, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Sep 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Malou P H SchreursMarilyn J Cipolla
Dec 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birthe SchnegelsbergDebra A Cockayne
Jul 25, 2009·American Journal of Physiology. Renal Physiology·Bopaiah P CheppudiraMargaret A Vizzard
Nov 5, 2010·American Journal of Physiology. Renal Physiology·Beatrice M GirardMargaret A Vizzard
Feb 19, 2010·American Journal of Physiology. Renal Physiology·Kimberly CorrowMargaret A Vizzard
Dec 25, 2009·American Journal of Physiology. Renal Physiology·Lauren ArmsMargaret A Vizzard
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Mary Beth Klinger, Margaret A Vizzard
Jun 19, 2013·Neurourology and Urodynamics·Célia Duarte Cruz
Apr 27, 2011·Neurourology and Urodynamics·Peter OchodnickýMartin C Michel
May 9, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoki YoshimuraTeruyuki Ogawa
May 15, 2015·TheScientificWorldJournal·Eric J GonzalezMargaret A Vizzard
May 6, 2016·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Oct 25, 2016·Experimental Neurology·Beatrice GirardMargaret A Vizzard
Sep 15, 2011·Developmental Neurobiology·Robert W HamillMargaret A Vizzard
Apr 19, 2013·American Journal of Physiology. Renal Physiology·Lauren ArmsMargaret A Vizzard
May 10, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liana MerrillMargaret A Vizzard
Jun 27, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liana Merrill, Margaret A Vizzard
Jun 18, 2019·Current Neuropharmacology·Ana CoelhoCélia Duarte Cruz
Aug 1, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gerald C MinginMark T Nelson
Mar 28, 2018·The Journal of Clinical Investigation·Jae Cheon RyuSung Ok Yoon
May 29, 2018·Neurourology and Urodynamics·Irina V ZabbarovaAnthony J Kanai

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