p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.

Journal of Cellular Physiology
Meritxell GironellaJuan L Iovanna

Abstract

The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In this work we describe another example of such mechanism, by which p8 binds and negatively regulates MSL1, a histone acetyl transferase (HAT)-associated protein, which in turn binds the DNA-damage-associated 53BP1 protein to facilitate DNA repair following DNA gamma-irradiation. Contrary to the HAT-associated activity, MSL1-dependent DNA-repair activity is almost completely dependent on 53BP1 expression. The picture that has emerged from our findings is that 53BP1 could be a scaffold that gets the HAT MSL1-dependent DNA-repair activity to the sites of DNA damage. Finally, we also found that, although p8 expression is transiently activated after gamma-irradiation, it is eventually submitted to sustained down-regulation, presumably to allow development of MSL1-associated DNA-repair activity. We conclude that interaction of MSL1 with 53BP1 brings MSL1-dependent HAT activity to the vicinity of damaged DNA. MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8,...Continue Reading

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Citations

Nov 21, 2009·The Journal of Biological Chemistry·Sandro Goruppi, Juan Lucio Iovanna
Dec 7, 2011·Molecular and Cellular Biology·Nikita AvvakumovJacques Côté
May 9, 2012·The Journal of Clinical Investigation·Tewfik HamidiJuan Lucio Iovanna
Jul 23, 2013·PloS One·Zheng LaiStephen Rea
Nov 10, 2013·PloS One·David Aguado-LleraJuan L Iovanna
Feb 24, 2011·Journal of Cellular Physiology·Maria Jose SandiJuan L Iovanna
Jul 27, 2010·Journal of Cellular Physiology·Carla E CanoJuan L Iovanna
Sep 11, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaotong GuoYukuan Feng
Mar 29, 2019·The Journal of Clinical Investigation·Patricia Santofimia-CastañoJuan Iovanna
May 28, 2019·Molecular Cancer·Yitao GongChen Liu
Aug 27, 2014·Head and Neck Pathology·Christopher BinghamKalu U E Ogbureke
Nov 20, 2018·Scientific Reports·Patricia Santofimia-CastañoJuan Iovanna
Jan 30, 2021·Nature Communications·Jiao LiuDaolin Tang
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Lei JiangZhensheng Qin
Mar 8, 2020·Cellular and Molecular Gastroenterology and Hepatology·Paula S Montenegro-MirandaVanesa Muncan
Sep 30, 2021·International Journal of Radiation Biology·Sally A Amundson

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