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p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

bioRxiv

Dec 29, 2013

Senthil K RadhakrishnanRaymond J Deshaies

Abstract

Proteasome inhibition elicits an evolutionarily conserved response wherein proteasome subunit mRNAs are upregulated, resulting in recovery (i.e. 'bounce-back') of proteasome activity. We previously demonstrated that the transcription factor Nrf1/NFE2L1 mediates this homeostatic response...read more

Mentioned in this Paper

NFE2L1 gene
NRF1 gene
Cleaved
Multicatalytic endopeptidase complex
Proteasome Function Inhibition
Proteolytic Processing
Nuclear Respiratory Factor 1
Antibody Fragments
Proteasome Activity
Endoplasmic Reticulum, Membrane
6
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p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

bioRxiv

Dec 29, 2013

Senthil K RadhakrishnanRaymond J Deshaies

PMID: 990001602

DOI: 10.1101/001602

Abstract

Proteasome inhibition elicits an evolutionarily conserved response wherein proteasome subunit mRNAs are upregulated, resulting in recovery (i.e. 'bounce-back') of proteasome activity. We previously demonstrated that the transcription factor Nrf1/NFE2L1 mediates this homeostatic response...read more

Mentioned in this Paper

NFE2L1 gene
NRF1 gene
Cleaved
Multicatalytic endopeptidase complex
Proteasome Function Inhibition
Proteolytic Processing
Nuclear Respiratory Factor 1
Antibody Fragments
Proteasome Activity
Endoplasmic Reticulum, Membrane
6

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