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p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

bioRxiv

Dec 29, 2013

Senthil K RadhakrishnanRaymond J. Deshaies

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Abstract

Proteasome inhibition elicits an evolutionarily conserved response wherein proteasome subunit mRNAs are upregulated, resulting in recovery (i.e. 'bounce-back') of proteasome activity. We previously demonstrated that the transcription factor Nrf1/NFE2L1 mediates this homeostatic response...read more

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Multicatalytic endopeptidase complex
Cleaved Cell
Gene Expression
Species
Structure of Lumen of Body System
Proteasome Complex Location (Sensu Eukarya)
Cavity of Endoplasmic Reticulum Cistern
SVIP protein, human
Cleaved
Proteasome Pathway
6
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  • p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

    bioRxiv

    Dec 29, 2013

    Senthil K RadhakrishnanRaymond J. Deshaies

    PMID: 990001602

    DOI: 10.1101/001602

    Abstract

    Proteasome inhibition elicits an evolutionarily conserved response wherein proteasome subunit mRNAs are upregulated, resulting in recovery (i.e. 'bounce-back') of proteasome activity. We previously demonstrated that the transcription factor Nrf1/NFE2L1 mediates this homeostatic response...read more

    Mentioned in this Paper

    Multicatalytic endopeptidase complex
    Cleaved Cell
    Gene Expression
    Species
    Structure of Lumen of Body System
    6

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