PAC clone containing the HMGI(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line

Genes, Chromosomes & Cancer
B KazmierczakJ Bullerdiek

Abstract

Akin to the HMGI-C rearrangements observed in benign solid tumors with 12q14-15 abnormalities, the HMGI(Y) gene has been assumed to play a crucial role in tumors with 6p21 abnormalities. Fluorescence in situ hybridization (FISH) studies using a PAC clone containing the HMGI(Y) gene as a molecular probe have been performed on a cell line from a uterine leiomyoma with a complex translocation involving chromosomal band 6p21.3. The results revealed that the breakpoint mapped within the PAC clone as reflected by signals on the normal chromosome 6 and both derivative chromosomes 1 and 14. Thus, the breakpoint was located within the HMGI(Y) gene or its close vicinity. These findings support the idea that HMGI(Y) rearrangements are causally related to the origin of uterine leiomyomas with 6p21 abnormalities.

References

May 1, 1990·Genes, Chromosomes & Cancer·M Nibert, S Heim
Sep 1, 1988·Cancer Genetics and Cytogenetics·L BoghosianA A Sandberg
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Citations

Sep 1, 1999·Genes, Chromosomes & Cancer·J Bullerdiek
Oct 24, 2002·Cancer Genetics and Cytogenetics·Azra H LigonCynthia C Morton
May 1, 1997·Cancer Genetics and Cytogenetics·P Dal Cin, H Van den Berghe
Feb 12, 1999·Cancer Genetics and Cytogenetics·P PolitoH Van den Berghe
May 29, 1999·Cancer Genetics and Cytogenetics·C RohenJ Bullerdiek
Jan 7, 1999·Breast Cancer Research and Treatment·C Lundin, F Mertens
May 10, 2001·Clinical Obstetrics and Gynecology·K L Gross, C C Morton
Aug 22, 2015·Expert Opinion on Therapeutic Targets·Dominique N MarkowskiJörn Bullerdiek
Jul 16, 2009·Cancer Genetics and Cytogenetics·Anke van RijkEric F P M Schoenmakers
Mar 18, 2005·Cancer Genetics and Cytogenetics·Avery A Sandberg
Jul 31, 2004·American Journal of Obstetrics and Gynecology·Sherman Elias
Feb 26, 1999·Genomics·B KazmierczakJ Bullerdiek
Oct 19, 2016·Expert Review of Anticancer Therapy·Birgit RommelJörn Bullerdiek
Mar 1, 2006·Obstetrics and Gynecology Clinics of North America·Melissa K LobelCynthia C Morton
Sep 18, 1997·Genes, Chromosomes & Cancer·P Dal CinH Van den Berghe
Dec 29, 2015·International Journal of Oncology·Ioannis PanagopoulosSverre Heim
Jul 9, 2008·Archives of Pathology & Laboratory Medicine·Alain C Borczuk

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