PMID: 9437741Jan 23, 1998Paper

PACAP 1-38 as an inhaled bronchodilator in guinea pigs in vivo

Peptides
A LindénJ A Nadel

Abstract

The effect on total pulmonary resistance (R1) was examined for inhaled PACAP 1-38, PACAP 1-27 and VIP in anesthetized, ventilated guinea pigs. Two minutes after inhalation, PACAP 1-38 (36 +/- 6%), PACAP 1-27 (42 +/- 9%) and VIP (48 +/- 19%) inhibited the increase in R1 (% inhibition of histamine-induced R1 prior to inhalation) caused by histamine i.v., whereas the vehicle (-1 +/- 10%) did not. This inhibitory effect lasted five times longer for PACAP 1-38 (> 50 min) than for PACAP 1-27 and VIP (< 10 min). The inhaled peptides caused no sustained effects on heart rate or blood pressure. Infusion of PACAP 1-38 i.v. dose-dependently inhibited the increase in R1 caused by inhaled histamine and by carbachol i.v..

Citations

Apr 9, 1998·Peptides·S YoshiharaS Watanabe
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J KinhultL O Cardell
Jul 20, 2007·European Journal of Clinical Investigation·D DobererV Petkov
Nov 3, 2004·Regulatory Peptides·Shigemi YoshiharaOsamu Arisaka
Jul 23, 2015·Oxidative Medicine and Cellular Longevity·Mounira TliliOlfa Tebourbi
Sep 29, 1999·Pulmonary Pharmacology & Therapeutics·L Lindén
Jan 8, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachel A RossNaomi M Simon
Feb 24, 2001·Annals of the New York Academy of Sciences·R BustoJ C Prieto

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