PMID: 9416988Aug 15, 1997Paper

PACAP-induced plasma extravasation in rat skin

Regulatory Peptides
L O CardellJ A Nadel

Abstract

The effects of pituitary adenylate cyclase activating peptide (PACAP) 38, PACAP 27 and vasoactive intestinal peptide (VIP) on plasma extravasation were investigated in vivo in rat skin. PACAP 38, PACAP 27 and VIP, caused concentration-dependent extravasation in rat skin. The order of potency was PACAP 38 > PACAP 27 = VIP, whereas the order of maximal induced extravasation was PACAP 38 = PACAP 27 > VIP, suggesting that PACAP 38 might be the most powerful inducer of plasma extravasation of the three tested members of the secretin-glucagon-VIP family. Substance P (SP) was about 5 times more potent than PACAP 38 and 15 times more potent than PACAP 27. These data indicate that PACAP 38 induced plasma extravasation in concentrations roughly equimolar to SP. Pyrilamine (H1 receptor antagonist) reduced the PACAP 38-induced plasma extravasation more than 50%; cimetidine (H2 receptor antagonist) was without effect. To investigate whether a cAMP-mediated process is involved in the induction of plasma extravasation, the synthetic adenosine 3',5'-cyclic monophosphate (cAMP), dibutyryl adenosine cyclic monophosphate (DBcAMP) and the cAMP-inducing drug, salbutamol, were each injected in the skin; neither of these drugs caused extravasation. W...Continue Reading

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Citations

Aug 24, 1999·Regulatory Peptides·A Schmidt-ChoudhuryB K Wershil
Oct 18, 2002·Peptides·Johan KinhultLars Olaf Cardell
Feb 13, 1999·Progress in Neurobiology·M J Millan
May 17, 2000·Burns : Journal of the International Society for Burn Injuries·L LindblomP Löwhagen Hendén
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J KinhultL O Cardell
Oct 28, 2003·The Journal of Physiology·Lionel FizanneBérengère Fromy
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jérémy ChéretChristelle Le Gall-Ianotto
Oct 5, 2010·The American Journal of Pathology·Stephan SeeligerMartin Steinhoff
Sep 29, 1999·Pulmonary Pharmacology & Therapeutics·L Lindén
Jul 8, 2017·International Journal of Molecular Sciences·Anna KozłowskaMariusz Majewski
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
Jan 7, 2020·Neuropeptides·Ana Karen Sandoval-TalamantesAnabell Alvarado-Navarro
Feb 28, 2019·Dermatology : International Journal for Clinical and Investigative Dermatology·Devina Mehta, Richard D Granstein

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