PMID: 8993476Dec 26, 1996Paper

PACAP occurs in sensory nerve fibers and participates in ocular inflammation in the rabbit

Annals of the New York Academy of Sciences
Z Y WangR Håkanson

Abstract

PACAP is a sensory neuropeptide; it occurs together with CGRP in a population of C fibers in the rabbit eye. PACAP is likely to be involved in the inflammatory response in as much as PACAP-induced responses mimic the symptoms of inflammation and because the concentration of PACAP-LI in the aqueous humor increased greatly in response to noxious stimuli. The observation that capsaicin releases both PACAP and CGRP from the iris and ciliary body supports the view that PACAP is present in C fibers in the rabbit eye.

References

Jan 1, 1990·Journal of Ocular Pharmacology·W G Unger
Jul 15, 1987·Experientia·R A StoneA M Laties
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K KrootilaA Palkama
Feb 21, 1994·European Journal of Pharmacology·S F Nilsson
Oct 29, 1993·Biochimica Et Biophysica Acta·J Christophe

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Citations

Aug 9, 2020·Frontiers in Endocrinology·Denes TothDora Reglodi
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M BraasMargaret A Vizzard

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