Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells

Molecular Carcinogenesis
Hui LingKa-yun Ng

Abstract

Aberrant arachidonic acid (AA) metabolism has been involved in inflammation and carcinogenesis. The key enzymes in AA metabolism such as cytosolic phospholipase A2 (cPLA(2)) and cyclooxygenase-2 (COX-2) have been implicated in the development and progression of many human cancers, including lung cancer. Hence, the blockade of these enzymes may suppress promotion and survival of human cancer cells. We and others have shown that a natural triterpenoid, pachymic acid (PA), can exhibit antiinflammatory and anticancer properties; however, its potential mechanism has not been fully clarified. In this study, we examined the effect of PA on the proliferation of human nonsmall cell lung cancer A549 cells. Furthermore, we investigated the influences of nontoxic levels of PA on AA metabolism. Additionally, the cellular events and signal transduction pathways influenced by PA were also examined. Our results showed that PA (1) inhibited anchorage-dependent and -independent A549 growth in a concentration-dependent manner, (2) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells, and at nonlethal levels, (3) decreased IL-1 beta-induced activation of cPLA(2) and COX-2, (4) suppressed IL-1 beta-induced activation of mi...Continue Reading

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Citations

Nov 4, 2016·Journal of Natural Products·Kuei-Hung LaiYang-Chang Wu
Oct 25, 2012·Expert Opinion on Investigational Drugs·Min HuangYi-Tao Wang
Apr 18, 2017·Ultrastructural Pathology·Yan-Hua ZhangRong-Qing Li
Oct 21, 2020·Cancer Letters·Zhangxiao PengChangqing Su
May 4, 2021·Bioorganic Chemistry·Xueyan SunGuotao Tang
Oct 25, 2012·Journal of Natural Products·José-Luis RíosRosa-María Giner

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