Paclitaxel alters sensory nerve biomechanical properties

Journal of Biomechanics
Brian G Bober, Sameer B Shah

Abstract

Paclitaxel is an effective chemotherapeutic that, despite its common use, frequently causes debilitating peripheral sensory neuropathy. Paclitaxel binds to and stabilizes microtubules, and through unknown mechanisms, causes abnormal microtubule aggregation. Given that microtubules contribute to the mechanical properties of cells, we tested the hypothesis that paclitaxel treatment would alter the stiffness of sensory nerves. Rat sural nerves were excised and soaked in Ringer's solution with or without paclitaxel. Nerves were secured between a force transducer and actuator, and linearly strained. Stress-strain curves were generated, from which elastic moduli were calculated. Paclitaxel treated nerves exhibited significantly higher moduli in both linear and transition regions of the curve. A composite-tissue model was then generated to estimate the stiffness increase in the cellular fraction of the nerve following paclitaxel treatment. This model was supported experimentally by data on mechanical properties of sural nerves stripped of their epineurium, and area fractions of the cellular and connective tissue components of the rat sural nerve, calculated from immunohistochemical images. Model results revealed that the cellular comp...Continue Reading

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Citations

Jan 31, 2019·Muscle & Nerve·Jaemyoung SungSameer B Shah
Apr 20, 2017·Current Neurology and Neuroscience Reports·Comana Cioroiu, Louis H Weimer
Jul 20, 2020·Cancer Chemotherapy and Pharmacology·Chou-Ching K LinMing-Shaung Ju
Mar 27, 2019·International Journal of Molecular Sciences·Renata ZajączkowskaJerzy Wordliczek
Dec 2, 2020·Journal of Biomechanics·Rishi S GuptaSameer B Shah
Jul 22, 2021·Current Cancer Drug Targets·Diala MerhebHazem I Assi

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