PMID: 9007128Dec 1, 1996Paper

Paclitaxel and carboplatin: a phase I study in advanced non-small cell lung cancer

Seminars in Oncology
A PaccagnellaL Ossana

Abstract

In the treatment of non-small cell lung cancer paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has significant activity and carboplatin has single-agent activity comparable with that of cisplatin, with less pronounced nonhematologic toxicity. The optimal doses of paclitaxel and carboplatin in combination have not been determined. We designed a phase I study combining a fixed paclitaxel dose of 175 mg/m2, administered either by 3- or 1-hour infusion, with escalating doses of carboplatin given every 4 weeks. The starting carboplatin dose was 175 mg/m2, with planned dose increases in increments of 25 mg/m2. The primary study objective was to find the maximum tolerated dose of the combination. Secondary objectives were to determine the toxicity profile, response rate, and feasibility of a 1-hour paclitaxel infusion with steroid premedication delivered only 1 hour before the paclitaxel infusion. Eligibility criteria included age 18 to 75 years, no prior chemotherapy, stage IIIB to IV disease, Eastern Cooperative Oncology Group performance status 0 to 2, no second tumors, measurable or evaluable disease, and informed consent. We achieved a carboplatin dose level of 300 mg/m2 without reaching the maximum tolerated dose...Continue Reading

Citations

Mar 8, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M C PerryM R Green
Nov 8, 2008·Pediatric Blood & Cancer·James I GellerUNKNOWN Pediatric Oncology Group study 9376

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