Abstract
The objective of this study was to assess the efficacy of chemotherapy in recurrent epithelial ovarian cancer using the sequential combination of 24-hr paclitaxel followed by cisplatin. All patients presenting to the Department of Gynecologic Oncology at Roswell Park Cancer Institute between April 1993 and May 1995 with recurrent epithelial ovarian cancer were offered enrollment in a prospective trial utilizing paclitaxel 135 mg/m2 administered in a continuous 24-hr intravenous infusion, followed by intravenous cisplatin 50 mg/m2. Forty-nine patients were entered into the study. Of 38 patients evaluable for response, there were 14 complete responders and 6 partial responders for an overall response rate of 53%. Median survival was >23 months for responders and 12 months for the entire study group. All complete responders were still alive with a median follow-up of 23 months. Of 12 evaluable patients whose tumors had progressed on single-agent paclitaxel, 4 achieved an objective response with the addition of cisplatin. Response rates and survival were similar in patients with platinum-resistant tumors compared to patients with platinum-sensitive tumors, and in patients who had received one, two, or multiple prior chemotherapy re...Continue Reading
Citations
Mar 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A L LeiserC Aghajanian
Feb 7, 2001·Cancer Investigation·D KhayatD Coeffic
Aug 2, 2012·Gynecologic Oncology·Ting GuiLina Guo
May 19, 2009·Gynecologic Oncology·Werner MeierJacobus Pfisterer
Sep 17, 2013·Pharmaceutical Biology·Jun Yu, Qi Chen
Oct 5, 2001·Gynecologic Oncology·B GronlundS A Engelholm
Aug 10, 2000·The Journal of Obstetrics and Gynaecology Research·S ShamsunderV Kochupillai
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Don S DizonDavid R Spriggs
Aug 10, 2000·Drugs & Aging·R E van Rijswijk, J B Vermorken
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·L M Chen, J S Berek
Feb 6, 2004·American Journal of Clinical Oncology·Gamal H EltabbakhRenate Adamowicz
Jul 7, 2000·Seminars in Surgical Oncology·L M Chen, B Y Karlan
Nov 9, 2019·Molecular Medicine Reports·Xian ZhangXiaoyu Wang
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P G RoseR McGehee