PMID: 9167743Jun 1, 1997Paper

Paclitaxel as a radiosensitizer combined with fractionated stereotactic radiotherapy in the treatment of recurrent medulloblastoma

American Journal of Clinical Oncology
D E GannettB Stea

Abstract

This report describes the treatment of a 39-year-old man with recurrent medulloblastoma previously treated with extensive chemotherapy and radiation therapy. A novel treatment technique combining paclitaxel (275 mg IV bolus) and fractionated stereotactic radiotherapy (30 Gy in six fractions over 3 weeks) was given to palliate the patient's significant neurologic symptoms. The patient experienced a significant improvement both radiographically and in the quality of his life at follow-up 5 months after completion of treatment. No toxicity has been observed. The treatment of medulloblastoma with paclitaxel and fractionated stereotactic radiotherapy, either alone or in combination, merits further investigation.

References

Feb 22, 1979·Nature·P B SchiffS B Horwitz
Sep 1, 1977·International Journal of Radiation Oncology, Biology, Physics·J Van DykJ R Cunningham
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S S GillM Brada
Feb 1, 1988·International Journal of Radiation Oncology, Biology, Physics·W LutzN Maleki
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P B Schiff, S B Horwitz
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·S L Brenner, B R Brinkley
Jan 1, 1984·Pharmacology & Therapeutics·J J Manfredi, S B Horwitz
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·N Gupta, D F Deen
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·M Barton
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·M A CahanH Brem
Mar 16, 1994·Journal of the National Cancer Institute·J LiebmannJ B Mitchell
Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J LiebmannJ B Mitchell
Aug 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L Minarik, E J Hall
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·M MenkeW Schlegel
Feb 1, 1993·Gynecologic Oncology·A SterenH E Averette
Jun 1, 1993·Cancer·H ChoyD D Von Hoff
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J GlantzM J Egorin

❮ Previous
Next ❯

Citations

Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·C LiS Wallace
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·M MachtayD I Rosenthal
Mar 15, 2001·Critical Reviews in Oncology/hematology·H Choy
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P ChastagnerC Kalifa
Feb 9, 1999·Medical and Pediatric Oncology·J E Wolff, R M Egeler
Feb 9, 2006·Pediatric Neurosurgery·Masamitsu AbeJunichi Imamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.