Paclitaxel as second and subsequent therapy for metastatic breast cancer: activity independent of prior anthracycline response

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A D SeidmanP Forsythe

Abstract

Two phase II clinical trials were performed to determine efficacy and tolerability of paclitaxel (Taxol; Bristol-Myers Squibb Co, Wallingford, CT) and granulocyte colony-stimulating factor ([G-CSF] Neupogen; Amgen, Inc, Thousand Oaks, CA) as second or subsequent therapy for metastatic breast cancer. Paclitaxel plus G-CSF was administered as a second stage IV regimen to 25 patients with metastatic breast cancer at a dose of 250 mg/m2 intravenously over 24 hours. Fifty-two patients received paclitoxel plus G-CSF at 200 mg/m2 as a third or subsequent regimen (no restriction on number of prior regimens or on prior high-dose chemotherapy). All patients had received prior anthracycline treatment, and ultimately had progressive bidimensionally measurable disease. Twenty-five of 76 patients (32.8%) had a major objective response (95% confidence interval [CI], 14% to 37%). The median duration of response was 7 months (range, 1 to 20+). Responses were as likely in patients with disease demonstrated to be unresponsive to anthracycline, ie, de novo resistance (11 of 37, or 30%) as in those with disease that once exhibited anthracycline sensitivity, ie, acquired resistance, (10 of 31, or 32%). G-CSF administration was associated with febril...Continue Reading

Citations

Oct 8, 1999·Journal of the National Cancer Institute·J E Groopman, L M Itri
Nov 21, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·L B MichaudG Hortobagyi
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BerrutiL Dogliotti
Mar 16, 2001·Expert Opinion on Pharmacotherapy·J M NabholtzJ Mackey
Jan 17, 2004·Drugs in R&D·Lazzaro RepettoLucia Del Mastro
May 4, 2005·Cancer Chemotherapy and Pharmacology·G P StathopoulosJ Xynotroulas
Dec 14, 2006·Current Oncology Reports·Alison K Conlin, Andrew D Seidman
Apr 22, 2011·Expert Review of Cardiovascular Therapy·Syed Wamique YusufJean-Bernard Durand
Oct 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J InghamR Portenoy
Feb 15, 1997·Medizinische Klinik·F Hartmann, M Pfreundschuh
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GennariP F Conte
May 18, 1999·Breast Cancer Research and Treatment·K KoshizukaH P Koeffler
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E A PerezR Patel
Dec 22, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Véronique DiérasPierre Pouillart
Aug 2, 2002·American Journal of Clinical Oncology·Faruk TasErkan Topuz
Jun 17, 2005·Expert Opinion on Pharmacotherapy·Jean-Marc Nabholtz, Joseph Gligorov
May 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleftherios P MamounasNorman Wolmark
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William M SikovMary Anne Fenton
Oct 6, 2010·Cancer Chemotherapy and Pharmacology·Aris PolyzosDimitris Mavroudis
Apr 9, 2009·Expert Opinion on Pharmacotherapy·Patrick G MorrisClifford A Hudis
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L Romero AcuñaB Leone
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J AlexandreE Cvitkovic
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KuererS E Singletary
Mar 11, 1998·Breast Cancer Research and Treatment·A TortorielloR V Iaffaioli
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P Cortazar, B E Johnson
May 23, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Jun KinoshitaTetsuro Kajiwara
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·G N HortobagyiL Asmar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.