Paclitaxel-eluting balloon and everolimus-eluting stent for provisional stenting of coronary bifurcations: 12-month results of the multicenter BIOLUX-I study

Cardiovascular Revascularization Medicine : Including Molecular Interventions
Stephen WorthleyIan T Meredith

Abstract

Several studies investigated the combination of bare metal stents in the main branch and drug-eluting balloons in the side branch in bifurcation lesions, but data on the combination of drug-eluting stents and drug-eluting balloons are scarce. We aim to assess the feasibility of provisional stenting with an everolimus-eluting stent in the main branch and a paclitaxel-eluting balloon in the side branch. In this prospective, multi-center study conducted in 5 Australian sites, 35 patients with bifurcation lesions were enrolled. Angiographic and intravascular ultrasound assessments were conducted at 9 months; clinical follow-up was conducted until 12 months. The primary endpoint, late lumen loss in the side branch measured by quantitative coronary angiography, was 0.10±0.43mm. No binary restenosis was observed. One patient died; 3 myocardial infarctions (one suspected and two in non-target vessels) and one target lesion revascularization occurred. No probable or definite stent thrombosis was observed. The combination of an everolimus-eluting stent in the main branch and a paclitaxel-eluting balloon in the side branch appears to be a safe, effective and novel treatment option for bifurcation lesions.

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Citations

Jul 9, 2016·International Journal of Cardiology·Bernardo CorteseFernando Alfonso
Jul 8, 2016·Cardiology and Therapy·Rasmus Kapalu Broge RichelsenSvend Eggert Jensen
Jan 27, 2018·Future Cardiology·Mostafa ElwanyBernardo Cortese
Jan 25, 2017·Herz·F KrackhardtB Kherad
Sep 2, 2018·Current Cardiology Reports·Rafael A Meneguz-MorenoAlexandre Abizaid
Nov 7, 2019·Future Cardiology·Dario BuccheriBernardo Cortese

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