PMID: 9416383Jan 7, 1998Paper

Paclitaxel-induced acute bilateral pneumonitis

The Annals of Pharmacotherapy
A KhanS Bilgrami

Abstract

To report three cases of paclitaxel-induced acute bilateral pneumonitis, as well as to ascertain its incidence and outcome. A total of 239 patients with a variety of underlying malignancies received 528 courses of paclitaxel-containing chemotherapy. Paclitaxel 200 mg/m2 was infused over 3 hours with standard premedication. Three patients developed bilateral interstitial infiltrates either during or within 6 hours of the administration of paclitaxel. Symptoms included a nonproductive cough, dyspnea, and sudden arterial oxygen desaturation. Response to parenteral corticosteroids was dramatic and reversed the process in all 3 patients. Paclitaxel-induced acute bilateral pneumonitis appears to be a rare adverse reaction. It may either be a direct toxic effect of the chemotherapeutic agent or an adverse effect of its Cremophor EL diluent. Although the exact pathophysiology is unclear, a variety of immune and nonimmune mechanisms have been postulated, including hypersensitivity reactions, release of cytokines from macrophages, and the possible role of prior thoracic irradiation. Acute bilateral pneumonitis occurs in less than 1% of individuals receiving 3-hour infusions of paclitaxel, and responds dramatically to parenteral corticost...Continue Reading

References

Jan 1, 1977·Annals of Internal Medicine·N J Gross
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R B TishlerE J Hall
Jul 11, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R B WeissB Leyland-Jones
Feb 18, 1989·Lancet·S J SiddallA J Nunn
Aug 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J O'DwyerB Leyland-Jones
Jun 1, 1995·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·W Akerley, H Choy
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J G TheisG Koren
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H L Goldberg, S B Vannice
Dec 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S LaskinM Morgan
Feb 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T Shenkier, K Gelmon
May 1, 1994·The Annals of Pharmacotherapy·R T Dorr
May 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M PeereboomE K Rowinsky
Jan 15, 1996·Annals of Internal Medicine·R K Ramanathan, C P Belani
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M Grunberg

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Citations

Dec 10, 2016·SpringerPlus·Ajay GuptaGeoffrey Beadle
Feb 27, 2001·AJR. American Journal of Roentgenology·P WongF E Stockdale
Nov 27, 2001·British Journal of Cancer·G S WangR P Perng
Dec 3, 2003·European Journal of Anaesthesiology·S KvolikI Karner
Jun 10, 2006·Expert Review of Anticancer Therapy·Sandy Srinivas, Natalia Colocci
Dec 19, 2012·Acta Oncologica·Eivind StoraasHans Petter Eikesdal
Mar 22, 2014·Molecular and Clinical Oncology·Hidemi KawajiriKosei Hirakawa
Nov 27, 2002·Cancer Investigation·Rachel Ash-BernalRodrigo Erlich
Jun 13, 2021·World Journal of Surgical Oncology·Kenji TezukaTakayo Ota
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W T LimB Chowbay

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