Paclitaxel-induced arterial wall toxicity and inflammation: part 2--long-term tissue response in a minipig model

Journal of Vascular and Interventional Radiology : JVIR
Ulrike StampflGoetz M Richter

Abstract

In part 1 of the present study, the authors demonstrated that coronary paclitaxel uptake from drug eluting stents (DESs) was not dependent on exposure time and dose. In this second part, the effect of the different paclitaxel dose densities on long-term biologic behavior was evaluated. In 40 minipigs, (with 4- and 12-week follow-up), identical stents with the same three paclitaxel dose densities as in part 1 were implanted in the right coronary artery. Minipigs implanted with Polyzene-F nanocoated stents served as the control group. Quantitative angiography measuring average luminal diameter (from three in-stent reference points), minimal luminal diameter (from the point of maximum in-stent stenosis), average late loss, maximum late loss, and binary stenosis rate was performed, as was microscopy to determine neointimal thickening, injury score, and inflammation. All three DESs were associated with a high average late loss, binary stenosis rate, and neointimal thickening, without significant differences. Drug-free stents had significantly less late in-stent stenosis: there was an average late loss of 0.3 mm +/- 0.3 in drug-free stents versus 0.8 mm +/- 0.2 in intermediate-dose stents and 1.5 mm +/- 0.6 in high-dose stents (P = ....Continue Reading

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Citations

Feb 1, 2011·Journal of Vascular and Interventional Radiology : JVIR·Gregory J Wilson
Jul 27, 2010·Journal of Vascular and Interventional Radiology : JVIR·Boris RadeleffGoetz M Richter
Oct 30, 2015·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Simone GrottiLeonardo Bolognese
Apr 9, 2021·Annals of Vascular Surgery·Bibombe Patrice MwipatayiUNKNOWN BIOLUX P-III Global Registry Investigators
Aug 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi ZhaoBowen Wang

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