Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis

Circulation
A W HeldmanJ P Froehlich

Abstract

Despite limiting elastic recoil and late vascular remodeling after angioplasty, coronary stents remain vulnerable to restenosis, caused primarily by neointimal hyperplasia. Paclitaxel, a microtubule-stabilizing drug, has been shown to inhibit vascular smooth muscle cell migration and proliferation contributing to neointimal hyperplasia. We tested whether paclitaxel-coated coronary stents are effective at preventing neointimal proliferation in a porcine model of restenosis. Palmaz-Schatz stents were dip-coated with paclitaxel (0, 0.2, 15, or 187 microgram/stent) by immersion in ethanolic paclitaxel and evaporation of the solvent. Stents were deployed with mild oversizing in the left anterior descending coronary artery (LAD) of 41 minipigs. The treatment effect was assessed 4 weeks after stent implantation. The angiographic late loss index (mean luminal diameter) decreased with increasing paclitaxel dose (P<0.0028 by ANOVA), declining by 84.3% (from 0.352 to 0.055, P<0.05) at the highest level tested (187 microgram/stent versus control). Accompanying this change, the neointimal area decreased (by 39.5%, high-dose versus control; P<0.05) with increasing dose (P<0.040 by ANOVA), whereas the luminal area increased (by 90.4%, high-do...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P B Schiff, S B Horwitz
Apr 1, 1995·The Journal of Clinical Investigation·S J SollottE K Rowinsky
Apr 13, 1995·The New England Journal of Medicine·E K Rowinsky, R C Donehower
Jan 31, 1998·Cardiovascular Research·D Brieger, E Topol
Jun 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A BaumbachK R Karsch
Jun 7, 2000·Journal of the American College of Cardiology·C HerdegK R Karsch

❮ Previous
Next ❯

Citations

Mar 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Martin OberhoffKarl R Karsch
Mar 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Bonnie L HiattAndrew J Carter
Aug 22, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A W Heldman, J A Brinker
Dec 25, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Soon Jun HongYoung Moo Ro
Dec 17, 2002·Journal of Biomedical Materials Research. Part a·Yasuhide NakayamaTakehisa Matsuda
Sep 11, 2007·Cardiovascular and Interventional Radiology·Dimitrios N LysitsasLampros K Michalis
Jul 6, 2005·Zeitschrift für Kardiologie·B SchellerG Nickenig
Dec 19, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Bruno SchellerMichael Boxberger
Mar 13, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Bodo CremersBruno Scheller
Jun 23, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Holger M NefAlbrecht Elsässer
Jun 10, 2003·Current Atherosclerosis Reports·Juan F GranadaAlbert Raizner
Jan 27, 2004·Advanced Drug Delivery Reviews·Amy C Richards GraysonMichael J Cima
Nov 26, 2003·European Journal of Pharmacology·Simon KennedyCherry L Wainwright
May 26, 2009·JACC. Cardiovascular Interventions·Yoriyasu SuzukiFumiaki Ikeno
Jul 23, 2003·The Journal of Surgical Research·Peter H LinStephen R Hanson
Mar 12, 2003·Advanced Drug Delivery Reviews·Jayanth Panyam, Vinod Labhasetwar
Oct 18, 2003·Journal of the American College of Cardiology·Bruno SchellerGeorg Nickenig
Oct 29, 2003·Cardiovascular Radiation Medicine·Yasuhide NakayamaHatsue Ishibashi-Ueda
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·P D WilliamsP A Kingston
Sep 28, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jochen GuckMichael Beil
Apr 18, 2003·The New England Journal of Medicine·Seung-Jung ParkGary S Mintz
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Nov 30, 2007·Journal of Endourology·Theodore VoudoukisDimitrios Siablis
Jun 18, 2005·Human Gene Therapy·Peter W RadkeEric W F W Alton
Jul 10, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Byung Ha LeeDae Joong Kim
May 25, 2002·Heart Disease·William H Frishman
Dec 19, 2006·Cardiology in Review·Leo SlavinJonathan M Tobis
Apr 17, 2007·Heart·Bruno SchellerMichael Böhm
Jun 24, 2004·Journal of Biomaterials Science. Polymer Edition·Namjin BaekKinam Park
Jan 7, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Weon KimJung Chaee Kang
Aug 12, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Amane KozukiKen-ichi Hirata
Oct 18, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Wen TianSigrid Nikol
Oct 10, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Benjamin Thierry, Maryam Tabrizian
Aug 3, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·John Waugh, Antona J Wagstaff
Nov 24, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Eberhard Grube, Lutz Buellesfeld
Jan 1, 2008·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Rohit KhuranaJonathan M Hill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.