PMID: 7547214Oct 1, 1995Paper

Paclitaxel (Taxol) in relapsed and refractory ovarian cancer: the UK and Eire experience

British Journal of Cancer
M E GoreJ M Thompson

Abstract

The purpose of our study was to investigate the efficacy and toxicity of paclitaxel in patients with relapsed or refractory epithelial ovarian cancer in the context of a large multicentre study performed in the UK and Eire. Patients with previously treated epithelial carcinoma of the ovary or fallopian tube who fulfilled the eligibility criteria were entered in the study. Eligibility criteria included: measurable or evaluable disease; Eastern Cooperative Oncology Group (ECOG) performance status 0-2; up to three prior chemotherapy regimens, one of which had to contain a platinum agent; adequate haematological, renal and hepatic function; and no significant cardiac history. Patients received either 175 mg m-2 or 135 mg m-2 paclitaxel. The lower dose was administered to patients who had received more than two prior chemotherapy regimens. Paclitaxel was given by i.v. infusion over 3 h every 21 days. Response was assessed at three-cycle intervals or earlier if required. A total of 155 patients were registered for the study in the UK of whom 140 were eligible for response and toxicity evaluation, and 12 patients were assessed for toxicity only. Hair loss was the most frequently reported toxicity, with 74% (119/152) of patients report...Continue Reading

Citations

Feb 7, 2001·Cancer Investigation·D KhayatD Coeffic
Jan 1, 2006·Women's Health·Gamal H Eltabbakh, Scott Goodrich
Nov 23, 2019·Expert Opinion on Emerging Drugs·Asaf MaozKoji Matsuo
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C J PooleD Roychowdhury
Dec 5, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C YamashiroT Hata
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G J RustinP McClean
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas J Herzog
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gordon J S RustinRaymond W Ruddon
Dec 22, 2012·ACS Medicinal Chemistry Letters·Lev G LisVadim J Gurvich

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