PACS-2: A key regulator of mitochondria-associated membranes (MAMs).

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Chenrui LiLin Sun

Abstract

Mitochondria-associated membranes (MAMs) are the organellar contact sites between mitochondria and the endoplasmic reticulum (ER), and recent studies demonstrated that MAMs, which serve as multiple scaffolds of proteins, are involved in Ca2+ signaling, lipid metabolism, mitochondrial morphology and functions, and autophagy. Importantly, several pathological conditions, such as obesity, diabetes mellitus and neurodegenerative diseases, indicate the significant role of MAMs in cellular homeostasis. Phosphofurin acidic cluster sorting protein 2(PACS-2), a multifunctional sorting protein at MAMs, plays a critical role in mitochondria, ER and lysosome homeostasis. In this review, we summarize the current understanding of the role of PACS-2 as a key regulator of MAMs and present the structure and other functions of PACS-2. Moreover, we describe the relationship between PACS-2 and diseases to reveal its potential as a novel therapeutic target that can be applied for the treatment of diseases.

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Citations

Dec 18, 2020·International Journal of Molecular Sciences·Fanny EysertMounia Chami
Dec 20, 2020·International Journal of Molecular Sciences·Yi Sun, Shuzhe Ding
Jun 19, 2021·Critical Reviews in Biochemistry and Molecular Biology·Zuzana NahackaJiri Neuzil
Jun 18, 2021·Oxidative Medicine and Cellular Longevity·Junxiong QiuShi Liang
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Xiaojiao WangSisi Wu
Aug 17, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rimpi Saikia, Jomon Joseph

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