Paediatric Anti-Müllerian Hormone measurement: Male and female reference intervals established using the automated Beckman Coulter Access AMH assay

Endocrinology, Diabetes & Metabolism
Helen JoplingLesley Tetlow

Abstract

Anti-Müllerian Hormone (AMH) concentration is high at birth in males, demonstrating the presence of functional testicular tissue in the prepubertal period, and acting as a useful marker in the investigation of paediatric reproductive disorders. AMH also provides a tool in the investigation of female virilization, premature ovarian failure and polycystic ovarian syndrome in childhood. Robust, assay-specific paediatric AMH reference intervals are therefore required for clinical interpretation of results. The aim of this study was to derive age-specific AMH reference intervals for males and females aged 0-18 years. Plasma samples were obtained from patients at Royal Manchester Children's Hospital and analysed for AMH using the automated Beckman Coulter Access AMH Assay. Patients under investigation for paediatric reproductive or endocrine disorders were excluded from the study. Seven hundred and 2 patient plasma samples (465 male, 237 female) were subject to AMH measurement, and results were analysed in order to derive continuous and discrete reference intervals for the paediatric age range. Clear discrimination between male and female AMH results was evident in the prepubertal age range, with some overlap between the genders foll...Continue Reading

References

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Citations

Feb 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Marloes NiesThera P Links
Mar 5, 2021·Annals of Clinical Biochemistry·Jin WangXijiang Hu
Jul 10, 2021·Fertility and Sterility·Francesca FilippiMonica Terenziani
Sep 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Roopa Kanakatti ShankarVeronica Gomez-Lobo

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Methods Mentioned

BETA
ELISA

Software Mentioned

R package Quantreg
Robust R package

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