Abstract
Introduction. Paediatric bacterial meningitis remains a costly disease, both financially and clinically.Hypothesis/Gap Statement. Previous epidemiological and cost studies of bacterial meningitis (BM) have largely focused on adult populations or single pathogens. There have been few recent, large-scale studies of pediatric BM in the USA.Aim. We examined healthcare resource utilization (HCRU) and associated morbidity and mortality of community-acquired versus nosocomial bacterial infections in children across the USA.Methodology. The IBM MarketScan Research databases were used to identify patients <18 years old admitted to USA hospitals from 2008 to 2015 with a primary diagnosis of BM. Cases were categorized as either community-acquired or nosocomial. HCRU, post-diagnosis neurosurgical procedures, 30-day in-hospital mortality, and complications were compared between groups. Multivariable regression adjusted for sex, age and Gram staining was used to compare costs of nosocomial versus community-acquired infections over time.Results. We identified 1928 cases of paediatric BM without prior head trauma or neurological/systemic complications. Of these, 15.4 % were nosocomial and 84.6 % were community-acquired infections. After diagno...Continue Reading
References
Jun 1, 1993·Archives of Neurology·H W PfisterK M Einhäupl
Sep 2, 1999·Infectious Disease Clinics of North America·A Pong, J S Bradley
Jan 4, 2007·JAMA : the Journal of the American Medical Association·Lise E NigrovicUNKNOWN Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics
May 8, 2008·JAMA : the Journal of the American Medical Association·Jillian MongelluzzoSamir S Shah
Jan 15, 2010·The New England Journal of Medicine·Diederik van de BeekAllan R Tunkel
Aug 5, 2010·The Pediatric Infectious Disease Journal·Aruna ChandranMathuram Santosham
Aug 31, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Jillian MongelluzzoSamir S Shah
Dec 25, 2010·Therapeutic Advances in Neurological Disorders·Olaf Hoffman, R Joerg Weber
May 27, 2011·The New England Journal of Medicine·Michael C ThigpenUNKNOWN Emerging Infections Programs Network
Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek
Jul 6, 2012·Archives of Disease in Childhood·Lise E NigrovicNathan Kuppermann
Jul 8, 2014·Vaccine·Bing WangHelen Marshall
Apr 16, 2015·Human Vaccines & Immunotherapeutics·Yi-Chien HoKow-Tong Chen
May 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liset OlarteSheldon L Kaplan
Apr 12, 2017·The Pediatric Infectious Disease Journal·Jesus G VallejoKristina G Hultén
Sep 19, 2017·Human Vaccines & Immunotherapeutics·Mehmet CeyhanEgemen Ozbilgili
Oct 31, 2018·Journal of Child Neurology·Liang HuoQingjun Cao
Nov 9, 2018·Frontiers in Neurology·Mei-Hsin HsuMing-Horng Tsai
Feb 15, 2019·Italian Journal of Pediatrics·Elena BozzolaAlberto Villani
Jun 6, 2019·BMC Infectious Diseases·Xi-Xi ZhangGang Liu