Paediatric reference intervals for 17 Roche cobas 8000 e602 immunoassays in the CALIPER cohort of healthy children and adolescents.

Clinical Chemistry and Laboratory Medicine : CCLM
Mary Kathryn BohnKhosrow Adeli

Abstract

Background The diagnostic utility of laboratory tests in paediatric medicine relies heavily on the availability of appropriate reference intervals (RIs). The Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) has established a comprehensive database of covariate-stratified RIs for many paediatric laboratory tests using a large, healthy reference population. Several automated analysers in widespread use in clinical laboratories have already been studied. Here, we extend the testing to Roche immunoassays and report, for the first time, comprehensive paediatric RIs for 17 endocrine and special chemistry markers. Methods A total of 741 healthy children and adolescents (1 day to <19 years) were recruited and serum samples were analysed for 17 immunoassays on the Roche cobas 8000 e602 Immunoassay Analyzer. Age and sex-specific RIs were established and corresponding 90% confidence intervals (CIs) were calculated in accordance with Clinical and Laboratory Standards Institute guidelines. Results Reference values for all analytes measured required age partitioning, particularly during early life and throughout adolescence. Of the 17 analytes measured, eight required sex partitioning, including ferritin, thyroid st...Continue Reading

References

Jul 1, 1976·The Biochemical Journal·M WorwoodA Jacobs
Jan 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·S L Jeffcoate
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·P CorbierJ Roffi
Oct 1, 1995·European Journal of Endocrinology·J Bernal, J Nunez
Sep 9, 2005·The Journal of Clinical Endocrinology and Metabolism·Leonard Wartofsky, Richard A Dickey
Sep 9, 2005·The Journal of Clinical Endocrinology and Metabolism·Martin I SurksGilbert H Daniels
Jul 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Ignacio BergadáRodolfo A Rey
Sep 14, 2006·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·Marcia J CooperMary R L'Abbé
Apr 3, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Satu-Liisa PauniahoMarkku Heikinheimo
Dec 15, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Cynthia K ColapintoMark S Tremblay
Sep 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Jeffrey R GarberUNKNOWN American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults
May 15, 2013·Reproductive Biomedicine Online·E A M KuijperC B Lambalk
May 17, 2015·Clinical Biochemistry·Mohamed Abou El HassanKhosrow Adeli
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jenny Clarkson, Allan E Herbison
Jul 21, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Victoria HigginsKhosrow Adeli
Jun 8, 2018·Critical Reviews in Clinical Laboratory Sciences·Houman TahmasebiKhosrow Adeli

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Citations

Feb 6, 2020·European Journal of Pediatrics·Veneranda MattielloUNKNOWN SPOG Pediatric Hematology Working Group
Feb 5, 2021·Clinical Biochemistry·Paula Argente Del CastilloAntonia Barcelo
Jun 30, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Mary Kathryn BohnKhosrow Adeli
Aug 8, 2021·Scientific Reports·Tatjana AmmerJakob Zierk
Nov 16, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Yu FuHeng Chen

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