Paenialvin A-D, four peptide antibiotics produced by Paenibacillus alvei DSM 29

The Journal of Antibiotics
Jia MengPeiyuan Qian

Abstract

Four peptide antibiotics, named paenialvin A-D, were isolated from Paenibacillus alvei DSM 29. Mass spectrum analysis determined the molecular masses of paenialvin A-D to be 1891, 1875, 1877, and 1923 Da, respectively. Tandem mass spectra and nuclear magnetic resonance (NMR) were used to elucidate their chemical structures. Paenialvin A-D showed antimicrobial activity against most strains that were tested, including methicillin-resistant Staphalococcus aureus, Staphylococcus aureus, Bacillus subtilis, Loktanella hongkongensis, Escherichia coli, and Pseudomonas aeruginosa. In particular, the minimum inhibitory concentration of paenialvins against Staphalococcus aureus reached 0.8-3.2 μg/mL. Although they were cytotoxic against HeLa cells at a concentration of 50 μg/mL, the lack of hemolysis by paenialvins confirmed that they are potential candidates for anti-tumor drugs.

References

Jan 1, 1977·Annual Review of Biochemistry·D R StormP E Swanson
Mar 6, 1998·Scientific American·S B Levy
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·Stuart B Levy
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E Falagas, Sofia K Kasiakou
Nov 11, 2005·International Journal of Systematic and Evolutionary Microbiology·P SahaT Chakrabarti
Oct 31, 2006·Applied and Environmental Microbiology·Zengguo HeAhmed E Yousef
Feb 24, 2009·Annual Review of Biochemistry·Hiroshi Nikaido
Jul 9, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·R Bhushan, H Brückner
Dec 27, 2011·Chemistry & Biology·Mohamed ShaheenSusan E Jensen
Mar 1, 2012·Applied and Environmental Microbiology·Yaoqi GuoAhmed E Yousef
Jan 7, 2015·Nature·Losee L LingKim Lewis
Aug 23, 2016·Nature Chemical Biology·Zhong-Rui LiPei-Yuan Qian

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Citations

Aug 15, 2020·Frontiers in Microbiology·Thomas EngAindrila Mukhopadhyay

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

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