Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase-9/2 in mice

European Journal of Pain : EJP
Y-X FanQ-P Li

Abstract

Recent studies have implicated that matrix metalloproteinase (MMP)-9 and MMP-2 play key roles in neuropathic pain due to their facilitation of inflammatory cytokine maturation and induction of neuroinflammation. However, the role of MMP-9/2 in postoperative pain is still unclear. We previously suggested that the natural compound paeoniflorin inhibited microglia activation induced by morphine treatment. In the present study, we demonstrated that paeoniflorin could alleviate postoperative pain via specific inhibition of matrix metalloproteinases (MMPs). Mice received a plantar incision surgery and their mechanical allodynia was assessed with von Frey filaments. The activity of MMP-9/2 was determined by gelatin zymography. Cell signalling was assayed by western blot and immunohistochemistry. The expression of MMP-9/2 was significantly increased in mice spinal cords with plantar incision surgery. Paeoniflorin remarkably suppressed the activity of MMP-9/2 and relieved plantar incision-induced mechanical allodynia. Interestingly, the administration of paeoniflorin blocked the maturation of interleukin-1β, which is a critical substrate of MMPs. Thereafter, paeoniflorin markedly suppressed microglia activation, inhibited the phosphoryl...Continue Reading

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Citations

Jul 22, 2018·Current Opinion in Anaesthesiology·Esther Pogatzki-ZahnPeter Zahn
Jan 9, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Piotr KamieniakTomasz Trojanowski
Oct 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qiliang ChenTetsuya Asakawa
Apr 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Fabiola Escolano-LozanoFrank Birklein

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