Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Qiang ZhangDaqing Jiang

Abstract

Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-1 reversed PF-inhibited proliferation and invasion, and knockdown of Notch-1 enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer.

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Citations

Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqiang WangPeigen Xiao
Aug 5, 2018·Journal of Cellular Biochemistry·Guanghui Wang, Nan Cheng
Dec 12, 2018·Journal of Cellular Physiology·Rasoul AbdollahzadehJavad Tavakkoly-Bazzaz
Nov 14, 2018·Journal of Cellular Physiology·Monireh KhordadmehrBehzad Baradaran
Mar 29, 2019·International Journal of Molecular Sciences·Cristina PorcheriThimios Mitsiadis
Dec 6, 2017·Molecular Medicine Reports·Hong ZhouShouchun Peng
Apr 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Baixia ZhangYun Wang
Nov 30, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Hao ChengYiming Pan
Dec 21, 2019·The Journal of Pharmacy and Pharmacology·Yongjing XiangYongxiang Gao
Sep 12, 2020·Molecular Pharmacology·Lobna Faiz GharaibehWalhan Alshaer
Aug 11, 2021·Journal of Mammary Gland Biology and Neoplasia·Weizhen ChenCheguo Cai

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