Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway

Phytotherapy Research : PTR
Zhengwang SunTae-Hoo Yi

Abstract

Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)-induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB-induced phosphorylation of mitogen-activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 expression, confirmed by greater nuclear accumulation of nuclear factor E2-releated factor 2 (Nrf2). Furthermore, this study proved that the endogenous antioxidant system Nrf2/antioxidant response element was regulated by dihydrolipoamide dehydrogenase, a tricarboxylic acid (TCA) cycle-associated protein whose level was decreased after UVB exposure. PS and PA promoted the production of dihydrolipoamide dehydrogenase, as well as the activation of Nrf2 and antioxidant response element, resulting in preventing procollagen type I ruined caused by UVB. In vivo, topical application of PS and PA attenuated UVB-induced matrix metalloproteinase-1 production a...Continue Reading

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Aug 19, 2014·Phytotherapy Research : PTR·Eunson HwangTae Hoo Yi
Oct 9, 2014·BMC Complementary and Alternative Medicine·Azila Abdul KarimNur Azilah Abdullah

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Citations

Sep 5, 2020·Antioxidants·Yong Chool Boo
Apr 22, 2020·Aging·Hongyi WangKai Tao
Oct 15, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saige YinXinwang Yang

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