PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle

British Journal of Pharmacology
A J CoyleC P Page

Abstract

1. Aerosol administration of platelet activating factor (PAF) to normal rabbits induced an enhanced airway responsiveness to inhaled histamine, 6 and 24 h after exposure. Following exposure to bovine serum albumin (BSA) as the carrier molecule for PAF, there was an increase in airway responsiveness to histamine 6 h after challenge, although by 24 h this was not significantly different from the responsiveness of airways to histamine before BSA. 2. PAF-induced bronchial hyperresponsiveness at 24 h was associated with a substantial increase in the number of neutrophils and mononuclear cells and a small, but significant increase in the number of eosinophils in the lungs as assessed by bronchoalveolar lavage. BSA exposure failed to alter the total number of cells in the lungs, although there was a significant increase in the number of neutrophils in the bronchoalveolar lavage fluid. 3. Selective platelet depletion with a guinea-pig anti-rabbit platelet serum inhibited PAF-induced bronchial hyperresponsiveness. In addition, there was an attenuation of PAF-induced airway inflammation in animals rendered thrombocytopenic. 4. The contractile potency to histamine, methacholine and carbachol was similar in intrapulmonary bronchi taken fro...Continue Reading

References

Apr 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L A AntonissenN L Stephens
Jan 1, 1990·British Journal of Clinical Pharmacology·J H WilkensJ C Frölich
Jan 1, 1989·Immunopharmacology·C P Page
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
May 1, 1988·Journal of Applied Physiology·W CibulasR T McKay
Jun 1, 1988·The American Review of Respiratory Disease·D N RobertsonP J Barnes
Nov 15, 1986·Lancet·C G Persson
Jan 1, 1987·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·T NakazawaS Kobayashi
Jan 1, 1989·The American Review of Respiratory Disease·A L JamesJ C Hogg
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Jan 1, 1987·Agents and Actions. Supplements·P GreseleG G Nenci
Dec 1, 1986·The Journal of Clinical Investigation·A J WardlawA B Kay
Feb 13, 1987·Biochemical and Biophysical Research Communications·N TamuraR G Townley
Feb 27, 1987·Biochemical and Biophysical Research Communications·D K Agrawal, R G Townley
Apr 1, 1987·British Journal of Pharmacology·P J BarnesD N Robertson
Aug 1, 1987·Journal of Applied Physiology·T W EvansP J Barnes
Aug 1, 1988·Journal of Applied Physiology·K J PopovichA R Leff
Jul 1, 1988·British Journal of Clinical Pharmacology·N M RobertsP J Barnes
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·C P Page
Oct 1, 1987·The American Review of Respiratory Disease·R R Schellenberg
Jul 1, 1987·Laboratory Animals·L A Brown
Sep 1, 1987·British Journal of Pharmacology·D N Robertson, C P Page
Nov 1, 1986·The American Review of Respiratory Disease·A TaytardP Freour
Apr 1, 1985·Journal of Applied Physiology·K F ChungW M Gold
Jan 1, 1984·International Archives of Allergy and Applied Immunology·R R Schellenberg, A Foster
Aug 1, 1984·The American Review of Respiratory Disease·P M O'ByrneM J Holtzman
May 1, 1981·British Journal of Pharmacology·K D Butler, J R Smith

Citations

Jan 7, 1992·European Journal of Pharmacology·S L UnderwoodD Raeburn
Apr 1, 1994·Pharmacology & Therapeutics·E R ChilversR A Challiss
Sep 1, 1993·British Journal of Pharmacology·C E Austin, J C Foreman
Jan 1, 1994·British Journal of Pharmacology·C M HerdC P Page
Feb 1, 1992·The American Review of Respiratory Disease·C P Page
Jul 27, 2007·Platelets·K N Kornerup, C P Page
Jan 1, 1993·Platelets·C M Herd, C P Page
Mar 14, 2009·The Journal of Allergy and Clinical Immunology·Risa Tamagawa-MineokaSaburo Kishimoto
May 26, 2007·The American Journal of Pathology·Risa Tamagawa-MineokaSaburo Kishimoto
Feb 17, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Risa Tamagawa-MineokaSaburo Kishimoto
Jun 9, 2015·The Journal of Allergy and Clinical Immunology·Marco IdzkoC P Page
Sep 18, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Risa Tamagawa-MineokaSaburo Kishimoto
Jan 1, 1991·Annals of the New York Academy of Sciences·C P Page

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here